p65

General Information (Source: NCBI Gene,UniProt)

Text mining Term	p65
UniProt ID	SYT1_MOUSE
Name	Synaptotagmin-1 p65 SytI Synaptotagmin I
Gene Names	Syt1
Taxonomy	Mus musculus

General annotation

Function	May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Subcellular location	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.

Function

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Subcellular location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.

Gene Ontology

GO:0048306	calcium-dependent protein binding	MF
GO:0005544	calcium-dependent phospholipid binding	MF
GO:0042584	chromaffin granule membrane	CC
GO:0042734	presynaptic membrane	CC
GO:0030672	synaptic vesicle membrane	CC
GO:0005886	plasma membrane	CC
GO:0043005	neuron projection	CC
GO:0016079	synaptic vesicle exocytosis	BP
GO:0005509	calcium ion binding	MF
GO:0005215	transporter activity	MF
GO:0016021	integral to membrane	CC
GO:0030054	cell junction	CC

Sequence

>gi|6678197|ref|NP_033332.1| synaptotagmin-1 isoform 1 [Mus musculus]
MVSASRPEALAAPVTTVATLVPHNATEPASPGEGKEDAFSKLKQKFMNELHKIPLPPWALIAIAIVAVLL
VVTCCFCVCKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEE
KLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQF
TFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSL
RYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFE
QIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVK
K

Database Cross Reference

Ensembl Gene	ENSMUST00000105276 ENSMUST00000064054
UniGene	Mm.289702
PDB
RefSeq	NP_033332.1
Pfam	PF00168

PTID

p65

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference