nestin

General Information (Source: NCBI Gene,UniProt)

Text mining Term nestin
UniProt ID NEST_RAT
Name Nestin
Gene Names Nes
Taxonomy Rattus norvegicus

General annotation

Function Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.
Subcellular location

Gene Ontology

GO:0030844 positive regulation of intermediate filament depolymerization BP
GO:0007420 brain development BP
GO:0005198 structural molecule activity MF
GO:0019215 intermediate filament binding MF
GO:0005882 intermediate filament CC
GO:0031730 CCR5 chemokine receptor binding MF
GO:2000179 positive regulation of neural precursor cell proliferation BP
GO:0030182 neuron differentiation BP
GO:0042493 response to drug BP
GO:0031667 response to nutrient levels BP
GO:0010212 response to ionizing radiation BP
GO:0031076 embryonic camera-type eye development BP
GO:0043066 negative regulation of apoptotic process BP

Sequence

>gi|6981262|ref|NP_037119.1| nestin [Rattus norvegicus]
MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLRAQSGDTSWRARADDELASLRILVDQR
WREKLEAEVQRDNLAEELESVAGRCQQVRLARERTVQEAACSRRALEAEKNARGWLSTQAAELERELEAL
RAAHEEERAHLNAQAACAPRRPPAPPHRIPGPAPEVEDLARRLGEVWRGAVRDYQERVAHMESSLGQARE
RLSQAVRGARECRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATDKFQLAVEALEQEKQGLQSQIA
QILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRGSQASLGFLDPKLKPNFLGIPEDQYLGSVLP
ALSPTSFPSPLPNTLETPVTAFLKTQEFLQARTPTLASTPIPPISEAPCPPNAEVRAQEVPLSLLQTQAP
EPLWLKATVPSSSAILPELEEPGGKQQGHFPDDLTSLATNLNPHHPTLEAKDGESSESRVSSIFQEDEGQ
IWELVEKEADIEVKVENSSAQKTQESGLDTEETQDSQGPLQKETLKALGEEPLMSLKIQNYETAGKENCN
SSTEGHLGTLEGPEKEKQIPLKSLEEKNVESEKTLENGVPVLSELLGKEDTRTEDQELMSPKGTLKRFSS
LGKESQEVVRPSKEGNLESWTAFKEESQHPLGFPGAEDQMLERLVEKEDQSFPRSPEEEDQEACRPLQKE
NQEPLGYEEAEGQILERLIEKESQESLRSPEEEDQEAGRSLQKENQEPLGYEEAEDQMLERLIEKESQES
LKSPEENQRIGKPLERENQKSLRYLEENQETFVPLESRNQRPLRSLEVEEEEQRIVKPLEKVSQDSLGSL
AEENVQPLRYLEEDDCINKSLLEDKTHKSLGSLEDRNGDSIIIPQESETQVSLRPPEEEDQRIVNHLEKE
SQEFSRSSEEEEQVMERSLEGENHESLSSVEKEDQMVESQLEKESQDSGKSLEDESQETFGPLEKENAES
LRSLAGQDQEEQKLEQETQQTLRAVGNEQMAVSPPEKVDPELPKPLGNDQEIARSLGKENQESLVSLKEK
GIETVKSLETEIIEPLETAEEDLERRKSIDTQEPLWSTEVARETVEPPEDEPPGSLGSVDENRETLTSLE
KESQELSSLGKWNVETRVEDSQQCLQVEEGLQEEQHQESLREVKQELPSSGNQQRWEDVVEGKAVGQEAP
LATTGVGTEDKAELHLRGQGGEEEAAAEGELLQDIVGEAWSLGSSEPKEQRVPAEALDNLEGGALEVPVA
QSMPEVTERDEDRAQAGEQDSIEVTLGLEAARTGLELEQEVVGLEDPRHFAREEAIPPSLGEESVKAKIA
QGLEGPGKEPKEAGALDSGILELPKTSSEALECQGHEESESMEGWEEEEASLETSDHEGSDAPQPRPPET
EEDEGAQAALTAPGPKLLEPCSPIPILTDAHELQPQAEGIQEAGWQPEAGSEALERVENEPEFGLGEIPE
GLQDWEEGREESEADDLGETLPDSTPLGLYLRSPASPKWDLAGEQRLSPQGDAGKEDWGPAVPAAQGLSG
PPEEEEEQGHGSDLSSEEFEDLGTEASLLPGVPKEVADHVGQVPPVLQPACWDQGGESDGFADEEESGEE
GEEEDADEEGAESGAQWWGSGASGGGCKVQDIAQRGDPVQESVGVSGLWDDGLRGAAANVPALEMVSQDS
AEPSGSEESESASLEGEEGQVTDHLDAPQEVTSMVPGVGDAFDIGGQSPNLDSEQVNGKMENGLEQAEGQ
VVLDGDEDQELLLQGQEVGALKVPLVASPVHLGPSQPLKFTLSGVDGDSWSSGED

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.9701
PDB
RefSeq NP_037119.1
Pfam PF00038