Melanopsin

General Information (Source: NCBI Gene,UniProt)

Text mining Term Melanopsin
UniProt ID OPN4_RAT
Name Melanopsin
Opsin-4
Gene Names Opn4
Taxonomy Rattus norvegicus

General annotation

Function Light receptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all- trans retinal back to 11-cis retinal.
Subcellular location Membrane; Multi-pass membrane protein. Note=Found in soma, dendrites and proximal part of axons of retinal ganglion cells.

Gene Ontology

GO:0018298 protein-chromophore linkage BP
GO:0016021 integral to membrane CC
GO:0007602 phototransduction BP
GO:0005502 11-cis retinal binding MF
GO:0007601 visual perception BP
GO:0042752 regulation of circadian rhythm BP
GO:0008020 G-protein coupled photoreceptor activity MF

Sequence

>gi|20302016|ref|NP_620215.1| melanopsin [Rattus norvegicus]
MNSPSESRVPSSLTQDPSFTASPALLQGIWNSTQNISVRVQLLSVSPTTPGLQAAAWVPFPTVDVPDHAH
YTLGTVILLVGLTGMLGNLTVIYTFCRNRGLRTPANMLIINLAVSDFLMSFTQAPVFFASSLYKKWLFGE
TGCKFYAFCGAVFGIVSMITLTAIAMDRYLVITRPLATIGMRSKRRTALVLLGVWLYALAWSLPPFFGWS
AYVPEGLLTSCSWDYVTFTPLVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGRACEGCGESPLRRR
QWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVGFAGYSHILTPYMSSVPAVIAKASAIHNPIIYAIT
HPKYRAAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGQKRQESLGSESEVGWTDT
ETTAAWGAAQQASGQSFCSHDLEDGEVKAPSSPQEQKSKTPKTKRHLPSLDRRM

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Database Cross Reference

Ensembl Gene ENSRNOT00000015642
UniGene Rn.54303
PDB
RefSeq NP_620215.1
Pfam PF00001