endothelin 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term endothelin 1
UniProt ID EDN1_RAT
Name Endothelin-1
Preproendothelin-1
ET-1
PPET1
Gene Names Edn1
Taxonomy Rattus norvegicus

General annotation

Function Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular location Secreted.

Gene Ontology

GO:0045987 positive regulation of smooth muscle contraction BP
GO:0042045 epithelial fluid transport BP
GO:0019229 regulation of vasoconstriction BP
GO:0001666 response to hypoxia BP
GO:0042554 superoxide anion generation BP
GO:0005615 extracellular space CC
GO:0001821 histamine secretion BP
GO:0034392 negative regulation of smooth muscle cell apoptosis BP
GO:0016049 cell growth BP
GO:0051899 membrane depolarization BP
GO:0071356 cellular response to tumor necrosis factor BP
GO:0046888 negative regulation of hormone secretion BP
GO:0051930 regulation of sensory perception of pain BP
GO:0033574 response to testosterone stimulus BP
GO:0071347 cellular response to interleukin-1 BP
GO:0090023 positive regulation of neutrophil chemotaxis BP
GO:0031707 endothelin A receptor binding MF
GO:0042482 positive regulation of odontogenesis BP
GO:0060137 maternal process involved in parturition BP
GO:0031708 endothelin B receptor binding MF
GO:0019233 sensory perception of pain BP
GO:0010259 multicellular organismal aging BP
GO:0007243 intracellular protein kinase cascade BP
GO:0032496 response to lipopolysaccharide BP
GO:0035094 response to nicotine BP
GO:0043200 response to amino acid stimulus BP
GO:0042493 response to drug BP

Sequence

>gi|6978791|ref|NP_036680.1| endothelin-1 preproprotein [Rattus norvegicus]
MDYFPVIFSLLFVAFQGAPETAVLGAELSPRAEKEVQSPPPSTSWRPRRSKRCSCSSLMDKECVYFCHLD
IIWVNTPERVVPYGLGSPSRSKRSLKDLLPTKTTDQGNRCQCAHQKDKKCWNFCQADKELRAQSTMQKGV
KDFKKGKPCPKLGKKCIYQQLVEGRKLRRLEAISNSIKTSFRVAKLKAELYRDQKLIHNRAH

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000019361
UniGene Rn.10918
PDB 6CMH
3CMH
RefSeq NP_036680.1
Pfam PF00322