| Text mining Term | gephyrin |
|---|---|
| UniProt ID | GEPH_RAT |
| Name |
Molybdopterin molybdenumtransferase MPT adenylyltransferase Putative glycine receptor-tubulin linker protein Gephyrin Domain E MPT Mo-transferase Domain G Molybdopterin adenylyltransferase |
| Gene Names |
Gphn
Synonyms:Gph |
| Taxonomy | Rattus norvegicus |
| Function |
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
|---|---|
| Subcellular location |
Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic face of glycinergic postsynaptic membranes. |
| GO:0032947 | protein complex scaffold | MF |
| GO:0060077 | inhibitory synapse | CC |
| GO:0005886 | plasma membrane | CC |
| GO:0005856 | cytoskeleton | CC |
| GO:0005524 | ATP binding | MF |
| GO:0005102 | receptor binding | MF |
| GO:0015631 | tubulin binding | MF |
| GO:0030054 | cell junction | CC |
| GO:0051260 | protein homooligomerization | BP |
| GO:0042803 | protein homodimerization activity | MF |
| GO:0016740 | transferase activity | MF |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | BP |
| GO:0005737 | cytoplasm | CC |
| GO:0030674 | protein binding, bridging | MF |
| GO:0007416 | synapse assembly | BP |
| GO:0045211 | postsynaptic membrane | CC |
| GO:0006605 | protein targeting | BP |
| GO:0046872 | metal ion binding | MF |
>gi|88853561|ref|NP_074056.2| gephyrin [Rattus norvegicus] MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETL IDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTL IINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGV QCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLS TASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDG MGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCG ADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGV TEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNE GISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVS AVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRL MSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.11032 |
| PDB |
1IHC 1T3E 2FU3 2FTS |
| RefSeq |
NP_074056.2 |
| Pfam |
PF03453 PF03454 PF00994 |