| Text mining Term | gephyrin |
|---|---|
| UniProt ID | GEPH_RAT |
| Name |
Molybdopterin molybdenumtransferase Domain E MPT adenylyltransferase Putative glycine receptor-tubulin linker protein Gephyrin MPT Mo-transferase Molybdopterin adenylyltransferase Domain G |
| Gene Names |
Gphn
Synonyms:Gph |
| Taxonomy | Rattus norvegicus |
| Function |
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
|---|---|
| Subcellular location |
Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic face of glycinergic postsynaptic membranes. |
| GO:0005737 | cytoplasm | CC |
| GO:0005524 | ATP binding | MF |
| GO:0030054 | cell junction | CC |
| GO:0032947 | protein complex scaffold | MF |
| GO:0042803 | protein homodimerization activity | MF |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | BP |
| GO:0005886 | plasma membrane | CC |
| GO:0030674 | protein binding, bridging | MF |
| GO:0046872 | metal ion binding | MF |
| GO:0045211 | postsynaptic membrane | CC |
| GO:0005856 | cytoskeleton | CC |
| GO:0007416 | synapse assembly | BP |
| GO:0016740 | transferase activity | MF |
| GO:0006605 | protein targeting | BP |
| GO:0005102 | receptor binding | MF |
| GO:0060077 | inhibitory synapse | CC |
| GO:0051260 | protein homooligomerization | BP |
| GO:0015631 | tubulin binding | MF |
>gi|88853561|ref|NP_074056.2| gephyrin [Rattus norvegicus] MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETL IDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTL IINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGV QCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLS TASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDG MGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCG ADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGV TEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNE GISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVS AVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRL MSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.11032 |
| PDB |
2FU3 2FTS 1IHC 1T3E |
| RefSeq |
NP_074056.2 |
| Pfam |
PF03453 PF03454 PF00994 |