| Text mining Term | gephyrin |
|---|---|
| UniProt ID | GEPH_RAT |
| Name |
Molybdopterin adenylyltransferase Gephyrin Molybdopterin molybdenumtransferase Domain G Putative glycine receptor-tubulin linker protein MPT adenylyltransferase Domain E MPT Mo-transferase |
| Gene Names |
Gphn
Synonyms:Gph |
| Taxonomy | Rattus norvegicus |
| Function |
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
|---|---|
| Subcellular location |
Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic face of glycinergic postsynaptic membranes. |
| GO:0006605 | protein targeting | BP |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | BP |
| GO:0016740 | transferase activity | MF |
| GO:0046872 | metal ion binding | MF |
| GO:0032947 | protein complex scaffold | MF |
| GO:0051260 | protein homooligomerization | BP |
| GO:0007416 | synapse assembly | BP |
| GO:0060077 | inhibitory synapse | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005524 | ATP binding | MF |
| GO:0042803 | protein homodimerization activity | MF |
| GO:0030054 | cell junction | CC |
| GO:0030674 | protein binding, bridging | MF |
| GO:0005886 | plasma membrane | CC |
| GO:0005102 | receptor binding | MF |
| GO:0045211 | postsynaptic membrane | CC |
| GO:0005856 | cytoskeleton | CC |
| GO:0015631 | tubulin binding | MF |
>gi|88853561|ref|NP_074056.2| gephyrin [Rattus norvegicus] MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETL IDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTL IINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGV QCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLS TASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDG MGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCG ADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGV TEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNE GISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVS AVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRL MSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.11032 |
| PDB |
2FU3 1T3E 2FTS 1IHC |
| RefSeq |
NP_074056.2 |
| Pfam |
PF03453 PF03454 PF00994 |