| Text mining Term | gephyrin |
|---|---|
| UniProt ID | GEPH_RAT |
| Name |
Molybdopterin molybdenumtransferase Domain G MPT adenylyltransferase Putative glycine receptor-tubulin linker protein Domain E MPT Mo-transferase Molybdopterin adenylyltransferase Gephyrin |
| Gene Names |
Gphn
Synonyms:Gph |
| Taxonomy | Rattus norvegicus |
| Function |
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
|---|---|
| Subcellular location |
Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic face of glycinergic postsynaptic membranes. |
| GO:0005886 | plasma membrane | CC |
| GO:0046872 | metal ion binding | MF |
| GO:0042803 | protein homodimerization activity | MF |
| GO:0005856 | cytoskeleton | CC |
| GO:0060077 | inhibitory synapse | CC |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | BP |
| GO:0045211 | postsynaptic membrane | CC |
| GO:0015631 | tubulin binding | MF |
| GO:0006605 | protein targeting | BP |
| GO:0007416 | synapse assembly | BP |
| GO:0032947 | protein complex scaffold | MF |
| GO:0016740 | transferase activity | MF |
| GO:0030674 | protein binding, bridging | MF |
| GO:0051260 | protein homooligomerization | BP |
| GO:0005737 | cytoplasm | CC |
| GO:0030054 | cell junction | CC |
| GO:0005524 | ATP binding | MF |
| GO:0005102 | receptor binding | MF |
>gi|88853561|ref|NP_074056.2| gephyrin [Rattus norvegicus] MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETL IDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTL IINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGV QCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLS TASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDG MGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCG ADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGV TEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNE GISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVS AVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRL MSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.11032 |
| PDB |
2FTS 2FU3 1IHC 1T3E |
| RefSeq |
NP_074056.2 |
| Pfam |
PF03454 PF00994 PF03453 |