| Text mining Term | gephyrin |
|---|---|
| UniProt ID | GEPH_RAT |
| Name |
Molybdopterin adenylyltransferase Putative glycine receptor-tubulin linker protein Domain E MPT adenylyltransferase Gephyrin Domain G MPT Mo-transferase Molybdopterin molybdenumtransferase |
| Gene Names |
Gphn
Synonyms:Gph |
| Taxonomy | Rattus norvegicus |
| Function |
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
|---|---|
| Subcellular location |
Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic face of glycinergic postsynaptic membranes. |
| GO:0032947 | protein complex scaffold | MF |
| GO:0005737 | cytoplasm | CC |
| GO:0051260 | protein homooligomerization | BP |
| GO:0045211 | postsynaptic membrane | CC |
| GO:0016740 | transferase activity | MF |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | BP |
| GO:0060077 | inhibitory synapse | CC |
| GO:0015631 | tubulin binding | MF |
| GO:0006605 | protein targeting | BP |
| GO:0042803 | protein homodimerization activity | MF |
| GO:0007416 | synapse assembly | BP |
| GO:0046872 | metal ion binding | MF |
| GO:0005524 | ATP binding | MF |
| GO:0005102 | receptor binding | MF |
| GO:0030674 | protein binding, bridging | MF |
| GO:0005886 | plasma membrane | CC |
| GO:0005856 | cytoskeleton | CC |
| GO:0030054 | cell junction | CC |
>gi|88853561|ref|NP_074056.2| gephyrin [Rattus norvegicus] MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETL IDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTL IINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGV QCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLS TASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDG MGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCG ADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGV TEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNE GISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVS AVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRL MSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.11032 |
| PDB |
1IHC 2FTS 2FU3 1T3E |
| RefSeq |
NP_074056.2 |
| Pfam |
PF00994 PF03453 PF03454 |