rhodopsin

General Information (Source: NCBI Gene,UniProt)

Text mining Term rhodopsin
UniProt ID OPSD_MOUSE
Name Rhodopsin
Gene Names Rho
Taxonomy Mus musculus

General annotation

Function Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
Subcellular location Membrane; Multi-pass membrane protein. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia (By similarity).

Gene Ontology

GO:0042622 photoreceptor outer segment membrane CC
GO:0071482 cellular response to light stimulus BP
GO:0060041 retina development in camera-type eye BP
GO:0006468 protein phosphorylation BP
GO:0060342 photoreceptor inner segment membrane CC
GO:0018298 protein-chromophore linkage BP
GO:0009881 photoreceptor activity MF
GO:0046872 metal ion binding MF
GO:0004930 G-protein coupled receptor activity MF
GO:0016021 integral to membrane CC

Sequence

>gi|21717805|ref|NP_663358.1| rhodopsin [Mus musculus]
MNGTEGPNFYVPFSNVTGVVRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRT
PLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVC
KPMSNFRFGENHAIMGVVFTWIMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVV
HFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWLPYASVAFYIFTHQG
SNFGPIFMTLPAFFAKSSSIYNPVIYIMLNKQFRNCMLTTLCCGKNPLGDDDASATASKTETSQVAPA

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Database Cross Reference

Ensembl Gene ENSMUST00000032471
UniGene Mm.2965
Mm.406156
PDB
RefSeq NP_663358.1
Pfam PF00001
PF10413