synaptophysin

General Information (Source: NCBI Gene,UniProt)

Text mining Term synaptophysin
UniProt ID SYPH_RAT
Name Synaptophysin
Major synaptic vesicle protein p38
Gene Names Syp
Taxonomy Rattus norvegicus

General annotation

Function Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Subcellular location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Gene Ontology

GO:0019717 synaptosome CC
GO:0030054 cell junction CC
GO:0005215 transporter activity MF
GO:0017075 syntaxin-1 binding MF
GO:0043234 protein complex CC
GO:0060076 excitatory synapse CC
GO:0030285 integral to synaptic vesicle membrane CC
GO:0044306 neuron projection terminus CC

Sequence

>gi|6981622|ref|NP_036796.1| synaptophysin [Rattus norvegicus]
MDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFR
LHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLA
TAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLW
VGNLWFVFKETGWAAPFMRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPASGG
GGYGPQGDYGQQGYGQQGAPTSFSNQM

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Database Cross Reference

Ensembl Gene
UniGene Rn.11067
PDB
RefSeq NP_036796.1
Pfam PF01284