D amino acid oxidase

General Information (Source: NCBI Gene,UniProt)

Text mining Term D amino acid oxidase
UniProt ID OXDA_RAT
Name D-amino-acid oxidase
DAO
DAAO
DAMOX
Gene Names Dao
Synonyms:Dao1
Taxonomy Rattus norvegicus

General annotation

Function Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Subcellular location Peroxisome.

Gene Ontology

GO:0005777 peroxisome CC
GO:0003884 D-amino-acid oxidase activity MF
GO:0000166 nucleotide binding MF

Sequence

>gi|16758434|ref|NP_446078.1| D-amino-acid oxidase [Rattus norvegicus]
MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSNPQEAEWNQQT
FDHLQSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKSTVLGFRKLTPSELDMFPDYSYGWFNTSLLLEG
KSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIK
HFILTHDPSLGIYNSPYIIPGSKTVTLGGVFQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMGELTG
FRPVRPQVRLERERLRFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKNLSRMPPSHL

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000000881
UniGene Rn.81058
PDB
RefSeq NP_446078.1
Pfam PF01266