| Text mining Term | mGluR1 |
|---|---|
| UniProt ID | GRM1_RAT |
| Name |
mGluR1 Metabotropic glutamate receptor 1 |
| Gene Names |
Grm1
|
| Taxonomy | Rattus norvegicus |
| Function |
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. |
|---|---|
| Subcellular location |
Cell membrane; Multi-pass membrane protein. |
| GO:0030424 | axon | CC |
| GO:0005887 | integral to plasma membrane | CC |
| GO:0019722 | calcium-mediated signaling | BP |
| GO:0051932 | synaptic transmission, GABAergic | BP |
| GO:0007206 | activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway | BP |
| GO:0004930 | G-protein coupled receptor activity | MF |
| GO:0001639 | PLC activating metabotropic glutamate receptor activity | MF |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | BP |
| GO:0014069 | postsynaptic density | CC |
| GO:0051899 | membrane depolarization | BP |
| GO:0051482 | elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger | BP |
| GO:0030331 | estrogen receptor binding | MF |
| GO:0014048 | regulation of glutamate secretion | BP |
| GO:0042734 | presynaptic membrane | CC |
| GO:0019233 | sensory perception of pain | BP |
>gi|8393487|ref|NP_058707.1| metabotropic glutamate receptor 1 isoform alpha precursor [Rattus norvegicus] MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEI REQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRC LPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTL QARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRER LPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSF DDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAM AHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEAN RYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEF TCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSREL CYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRF MSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYY AFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVW QRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSAHFSPPSSPSMVVHR RGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQQPPPQQPPQQPKSLMDQLQGVVTNFGS GIPDFHAVLAGPGTPGNSLRSLYPPPPPPQHLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYE REGNTEEDELEEEEDLPTASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILR DYKQSSSTL |
| Ensembl Gene |
ENSRNOT00000063916 |
|---|---|
| UniGene |
Rn.87787 |
| PDB |
1EWK 1EWV 1EWT 1ISS 1ISR |
| RefSeq |
NP_001107802.1 NP_058707.1 |
| Pfam |
PF01094 PF10606 PF00003 PF07562 |