enkephalin

General Information (Source: NCBI Gene,UniProt)

Text mining Term enkephalin
UniProt ID PENK_RAT
Name Met-enkephalin-Arg-Phe
PENK(114-133)
PENK(143-185)
OGF
Proenkephalin-A
Opioid growth factor
PENK(239-260)
Met-enkephalin
Synenkephalin
Met-enkephalin-Arg-Gly-Leu
Leu-enkephalin
Gene Names Penk
Taxonomy Rattus norvegicus

General annotation

Function Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(239-260) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
Subcellular location Secreted.

Gene Ontology

GO:0007218 neuropeptide signaling pathway BP
GO:0005576 extracellular region CC
GO:0001515 opioid peptide activity MF

Sequence

>gi|8393944|ref|NP_058835.1| proenkephalin-A precursor [Rattus norvegicus]
MAQFLRLCIWLVALGSCLLATVQADCSQDCAKCSYRLVRPGDINFLACTLECEGQLPSFKIWETCKDLLQ
VSKPEFPWDNIDMYKDSSKQDESHLLAKKYGGFMKRYGGFMKKMDELYPVEPEEEANGGEILAKRYGGFM
KKDADEGDTLANSSDLLKELLGTGDNRAKDSHQQESTNNDEDSTSKRYGGFMRGLKRSPQLEDEAKELQK
RYGGFMRRVGRPEWWMDYQKRYGGFLKRFAESLPSDEEGESYSKEVPEMEKRYGGFMRF

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000011892
UniGene Rn.10015
PDB
RefSeq NP_058835.1
Pfam PF01160