D amino acid oxidase

General Information (Source: NCBI Gene,UniProt)

Text mining Term D amino acid oxidase
UniProt ID OXDA_MOUSE
Name DAO
DAMOX
DAAO
D-amino-acid oxidase
Gene Names Dao
Synonyms:Dao1
Taxonomy Mus musculus

General annotation

Function Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Subcellular location Peroxisome.

Gene Ontology

GO:0006551 leucine metabolic process BP
GO:0003884 D-amino-acid oxidase activity MF
GO:0005777 peroxisome CC
GO:0000166 nucleotide binding MF

Sequence

>gi|110815857|ref|NP_034148.2| D-amino-acid oxidase [Mus musculus]
MRVAVIGAGVIGLSTALCIHERYHPTQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSNPQEAEWSQQT
FDYLLSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKNAVLGFRKLTPSEMDLFPDYGYGWFNTSLLLEG
KSYLPWLTERLTERGVKLIHRKVESLEEVARGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKH
FILTHDPSLGIYNSPYIIPGSKTVTLGGIFQLGNWSGLNSVRDHNTIWKSCCKLEPTLKNARIVGELTGF
RPVRPQVRLEREWLHFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKKLSRLPPSHL

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Database Cross Reference

Ensembl Gene ENSMUST00000112292
ENSMUST00000161610
UniGene Mm.20115
PDB 2DXO
RefSeq NP_034148.2
Pfam PF01266