NMDAR2C

General Information (Source: NCBI Gene,UniProt)

Text mining Term NMDAR2C
UniProt ID NMDE3_RAT
Name Glutamate [NMDA] receptor subunit epsilon-3
NMDAR2C
NR2C
N-methyl D-aspartate receptor subtype 2C
Gene Names Grin2c
Taxonomy Rattus norvegicus

General annotation

Function NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
Subcellular location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0030165 PDZ domain binding MF
GO:0030054 cell junction CC
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity MF
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex CC
GO:0045211 postsynaptic membrane CC
GO:0030288 outer membrane-bounded periplasmic space CC
GO:0047485 protein N-terminus binding MF
GO:0005234 extracellular-glutamate-gated ion channel activity MF
GO:0005261 cation channel activity MF

Sequence

>gi|148747563|ref|NP_036707.3| glutamate [NMDA] receptor subunit epsilon-3 [Rattus norvegicus]
MPALVSLQDPPVDMGGALGPALLLTSLLGAWARLGAGQGEQAVTVAVVFGSSGPLQTQARTRLTSQNFLD
LPLEIQPLTVGVNNTNPSSILTQICGLLGAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSA
VVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLD
VLTLELGPGGPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPA
AFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRHLLN
VTWEGRDFSFSPGGYLVRPTMVVIALNRHRLWEMVGRWDHGVLYMKYPVWPRYSTSLQPVVDSRHLTVAT
LEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDLTPYTKLCCKGFCIDILKKLAKVVKFSYDLYL
VTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGTVSPSAF
LEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKPGGPSFTIGKSVWLLWALVFNNSVPI
ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGS
TERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATT
GYGIAMQKDSHWKRAIDLALLQLLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMG
LALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPSPDLTADSAQANVLKML
QAARDMVNTADVSSSLDRATRTIENWGNNRRVPAPTASGPRSSTPGPPGQPSPSGWGPPGGGRTPLARRA
PQPPARPATCGPPLPDVSRPSCRHASDARWPVRVGHQGPHVSASERRALPERSLLPAHCHYSSFPRAERS
GRPYLPLFPEPPEPDDLPLLGPEQLARREAMLRAAWARGPRPRHASLPSSVAEAFTRSNPLPARCTGHAC
ACPCPQSRPSCRHLAQAQSLRLPSYPEACVEGVPAGVATWQPRQHVCLHAHTRLPFCWGTVCRHPPPCTS
HSPWLIGTWEPPAHRVRTLGLGTGYRDSGVLEEVSREACGTQGFPRSCTWRRVSSLESEV

Options for BLAST

Database:

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Database Cross Reference

Ensembl Gene ENSRNOT00000004477
UniGene Rn.9709
PDB
RefSeq NP_036707.3
Pfam PF00060
PF00497
PF10565
PF01094