oxytocin receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term oxytocin receptor
UniProt ID OXYR_RAT
Name OT-R
Oxytocin receptor
Gene Names Oxtr
Synonyms:Otr
Taxonomy Rattus norvegicus

General annotation

Function Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0034059 response to anoxia BP
GO:0042713 sperm ejaculation BP
GO:0005913 cell-cell adherens junction CC
GO:0060406 positive regulation of penile erection BP
GO:0060137 maternal process involved in parturition BP
GO:0032570 response to progesterone stimulus BP
GO:0070371 ERK1 and ERK2 cascade BP
GO:0005902 microvillus CC
GO:0043434 response to peptide hormone stimulus BP
GO:0005515 protein binding MF
GO:0010701 positive regulation of norepinephrine secretion BP
GO:0030431 sleep BP
GO:0016324 apical plasma membrane CC
GO:0007565 female pregnancy BP
GO:0060455 negative regulation of gastric acid secretion BP
GO:0070474 positive regulation of uterine smooth muscle contraction BP
GO:0034097 response to cytokine stimulus BP
GO:0017046 peptide hormone binding MF
GO:0060206 estrous cycle phase BP
GO:0001967 suckling behavior BP
GO:0004990 oxytocin receptor activity MF
GO:0042220 response to cocaine BP
GO:0048565 digestive tract development BP
GO:0051965 positive regulation of synapse assembly BP
GO:0042755 eating behavior BP
GO:0042711 maternal behavior BP
GO:0005000 vasopressin receptor activity MF
GO:0035176 social behavior BP
GO:0032355 response to estradiol stimulus BP
GO:0051968 positive regulation of synaptic transmission, glutamatergic BP
GO:0016021 integral to membrane CC
GO:0021537 telencephalon development BP
GO:0007613 memory BP
GO:0032230 positive regulation of synaptic transmission, GABAergic BP
GO:0042493 response to drug BP
GO:0007204 elevation of cytosolic calcium ion concentration BP
GO:0007507 heart development BP
GO:0001975 response to amphetamine BP

Sequence

>gi|9845279|ref|NP_037003.2| oxytocin receptor [Rattus norvegicus]
MEGTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHK
HSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLA
ICQPLRSLRRRTDRLAVLGTWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYVTWITLAVYI
VPVIVLAACYGLISFKIWQNLRLKTAAAAAAAEGNDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIV
LAFIVCWTPFFFVQMWSVWDVNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFFCCSARY
LKGSRPGETSVSKKSNSSTFVLSRRSSSQRSCSQPSSA

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Database Cross Reference

Ensembl Gene ENSRNOT00000007724
UniGene Rn.6841
PDB
RefSeq NP_037003.2
Pfam PF00001