cystathionine gamma lyase

General Information (Source: NCBI Gene,UniProt)

Text mining Term cystathionine gamma lyase
UniProt ID CGL_RAT
Name PRB-RA
Probasin-related antigen
Cystathionine gamma-lyase
Gamma-cystathionase
Gene Names Cth
Taxonomy Rattus norvegicus

General annotation

Function Catalyzes the last step in the transsulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure (By similarity).
Subcellular location Cytoplasm.

Gene Ontology

GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine BP
GO:0030170 pyridoxal phosphate binding MF
GO:0030308 negative regulation of cell growth BP
GO:0019346 transsulfuration BP
GO:0008285 negative regulation of cell proliferation BP
GO:0004123 cystathionine gamma-lyase activity MF
GO:0005737 cytoplasm CC
GO:0006749 glutathione metabolic process BP
GO:0080146 L-cysteine desulfhydrase activity MF
GO:0070814 hydrogen sulfide biosynthetic process BP
GO:0004121 cystathionine beta-lyase activity MF
GO:0019344 cysteine biosynthetic process BP

Sequence

>gi|8393215|ref|NP_058770.1| cystathionine gamma-lyase [Rattus norvegicus]
MQKDASSSGFLPSFQHFATQAIHVGPEPEQWSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCL
EKAVAALDGAKHCLTFARGLAATTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTK
LLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHKDIILVVDNTFMSAYFQRPLALGADICMCSAT
KYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLE
SNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELP
AIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAAHP

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.3881
PDB
RefSeq NP_058770.1
Pfam PF01053