ferritin heavy chain

General Information (Source: NCBI Gene,UniProt)

Text mining Term ferritin heavy chain
UniProt ID FRIH_MOUSE
Name Ferritin heavy chain
Ferritin H subunit
Gene Names Fth1
Synonyms:Fth
Taxonomy Mus musculus

General annotation

Function Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
Subcellular location

Gene Ontology

GO:0006879 cellular iron ion homeostasis BP
GO:0008285 negative regulation of cell proliferation BP
GO:0008199 ferric iron binding MF
GO:0004322 ferroxidase activity MF
GO:0005739 mitochondrion CC
GO:0006826 iron ion transport BP
GO:0006955 immune response BP

Sequence

>gi|6753912|ref|NP_034369.1| ferritin heavy chain [Mus musculus]
MTTASPSQVRQNYHQDAEAAINRQINLELYASYVYLSMSCYFDRDDVALKNFAKYFLHQSHEEREHAEKL
MKLQNQRGGRIFLQDIKKPDRDDWESGLNAMECALHLEKSVNQSLLELHKLATDKNDPHLCDFIETYYLS
EQVKSIKELGDHVTNLRKMGAPEAGMAEYLFDKHTLGHGDES

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Database Cross Reference

Ensembl Gene ENSMUST00000025563
UniGene Mm.1776
PDB
RefSeq NP_034369.1
Pfam PF00210