pituitary adenylate cyclase activating polypeptide

General Information (Source: NCBI Gene,UniProt)

Text mining Term pituitary adenylate cyclase activating polypeptide
UniProt ID PACA_MOUSE
Name PRP-48
PACAP38
PACAP-related peptide
Pituitary adenylate cyclase-activating polypeptide 27
PACAP-27
PACAP27
Pituitary adenylate cyclase-activating polypeptide
PACAP
PACAP-38
Pituitary adenylate cyclase-activating polypeptide 38
Gene Names Adcyap1
Synonyms:Pacap
Taxonomy Mus musculus

General annotation

Function Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity).
Subcellular location Secreted.

Gene Ontology

GO:0045786 negative regulation of cell cycle BP
GO:0051428 peptide hormone receptor binding MF
GO:0005184 neuropeptide hormone activity MF
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway BP
GO:0007190 activation of adenylate cyclase activity BP
GO:0007218 neuropeptide signaling pathway BP
GO:0005057 receptor signaling protein activity MF
GO:0005576 extracellular region CC

Sequence

>gi|6752982|ref|NP_033755.1| pituitary adenylate cyclase-activating polypeptide precursor [Mus musculus]
MTMCSGARLALLVYGIIMHSSVSCSPAAGLSFPGIRPEDEAYDQDGNPLQDFYDWDPPGVGSPASALRDA
YALYYPADRRDVAHEILNEAYRKVLDQLSARKYLQSVVARGAGENLGGSAVDDPAPLTKRHSDGIFTDSY
SRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL

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Database Cross Reference

Ensembl Gene ENSMUST00000064775
UniGene Mm.3407
PDB
RefSeq NP_033755.1
Pfam PF00123