catechol O methyltransferase

General Information (Source: NCBI Gene,UniProt)

Text mining Term catechol O methyltransferase
UniProt ID COMT_RAT
Name Catechol O-methyltransferase
Gene Names Comt
Taxonomy Rattus norvegicus

General annotation

Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Subcellular location Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side.

Gene Ontology

GO:0048609 multicellular organismal reproductive process BP
GO:0016021 integral to membrane CC
GO:0046500 S-adenosylmethionine metabolic process BP
GO:0042493 response to drug BP
GO:0005624 membrane fraction CC
GO:0048265 response to pain BP
GO:0016206 catechol O-methyltransferase activity MF
GO:0032496 response to lipopolysaccharide BP
GO:0007612 learning BP
GO:0045963 negative regulation of dopamine metabolic process BP
GO:0005886 plasma membrane CC
GO:0007565 female pregnancy BP
GO:0014070 response to organic cyclic compound BP
GO:0008210 estrogen metabolic process BP
GO:0000287 magnesium ion binding MF
GO:0042135 neurotransmitter catabolic process BP
GO:0005625 soluble fraction CC
GO:0050668 positive regulation of homocysteine metabolic process BP
GO:0046498 S-adenosylhomocysteine metabolic process BP
GO:0048662 negative regulation of smooth muscle cell proliferation BP

Sequence

>gi|6978681|ref|NP_036663.1| catechol O-methyltransferase [Rattus norvegicus]
MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNAKPGDPQSVLE
AIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAA
ITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLL
ADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSPDKS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000050269
UniGene Rn.220
PDB 3OZT
2CL5
3OE4
3HVJ
2ZTH
3HVH
1JR4
3HVI
3OZR
3OE5
2ZLB
3A7D
3HVK
3NW9
3OZS
2ZVJ
3NWE
3NWB
1VID
1H1D
RefSeq NP_036663.1
Pfam PF01596