catechol O methyltransferase

General Information (Source: NCBI Gene,UniProt)

Text mining Term catechol O methyltransferase
UniProt ID COMT_RAT
Name Catechol O-methyltransferase
Gene Names Comt
Taxonomy Rattus norvegicus

General annotation

Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Subcellular location Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side.

Gene Ontology

GO:0032496 response to lipopolysaccharide BP
GO:0045963 negative regulation of dopamine metabolic process BP
GO:0050668 positive regulation of homocysteine metabolic process BP
GO:0005886 plasma membrane CC
GO:0005625 soluble fraction CC
GO:0008210 estrogen metabolic process BP
GO:0048265 response to pain BP
GO:0046498 S-adenosylhomocysteine metabolic process BP
GO:0048609 multicellular organismal reproductive process BP
GO:0014070 response to organic cyclic compound BP
GO:0048662 negative regulation of smooth muscle cell proliferation BP
GO:0046500 S-adenosylmethionine metabolic process BP
GO:0005624 membrane fraction CC
GO:0016206 catechol O-methyltransferase activity MF
GO:0016021 integral to membrane CC
GO:0000287 magnesium ion binding MF
GO:0042135 neurotransmitter catabolic process BP
GO:0007612 learning BP
GO:0007565 female pregnancy BP
GO:0042493 response to drug BP

Sequence

>gi|6978681|ref|NP_036663.1| catechol O-methyltransferase [Rattus norvegicus]
MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNAKPGDPQSVLE
AIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAA
ITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLL
ADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSPDKS

Options for BLAST

Database:

Set subsequence:(optional):
From: To:

Optional parameters:
Expect:
Descriptions:

Database Cross Reference

Ensembl Gene ENSRNOT00000050269
UniGene Rn.220
PDB 1JR4
3HVH
3HVJ
3HVK
3OE5
2ZTH
2ZLB
3A7D
1H1D
3HVI
3OE4
3NWB
3NWE
2ZVJ
3OZS
3OZT
1VID
2CL5
3OZR
3NW9
RefSeq NP_036663.1
Pfam PF01596