delta aminolevulinic acid dehydratase

General Information (Source: NCBI Gene,UniProt)

Text mining Term delta aminolevulinic acid dehydratase
UniProt ID HEM2_RAT
Name ALADH
Porphobilinogen synthase
Delta-aminolevulinic acid dehydratase
Gene Names Alad
Taxonomy Rattus norvegicus

General annotation

Function Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
Subcellular location

Gene Ontology

GO:0005615 extracellular space CC
GO:0032025 response to cobalt ion BP
GO:0051597 response to methylmercury BP
GO:0033197 response to vitamin E BP
GO:0010266 response to vitamin B1 BP
GO:0046685 response to arsenic-containing substance BP
GO:0008270 zinc ion binding MF
GO:0045471 response to ethanol BP
GO:0009635 response to herbicide BP
GO:0051384 response to glucocorticoid stimulus BP
GO:0006979 response to oxidative stress BP
GO:0010043 response to zinc ion BP
GO:0070541 response to platinum ion BP
GO:0032791 lead ion binding MF
GO:0001666 response to hypoxia BP
GO:0042493 response to drug BP
GO:0010269 response to selenium ion BP
GO:0010039 response to iron ion BP
GO:0032496 response to lipopolysaccharide BP
GO:0005829 cytosol CC
GO:0010044 response to aluminum ion BP
GO:0043200 response to amino acid stimulus BP
GO:0014070 response to organic cyclic compound BP
GO:0010212 response to ionizing radiation BP
GO:0006783 heme biosynthetic process BP
GO:0046689 response to mercury ion BP
GO:0046686 response to cadmium ion BP
GO:0004655 porphobilinogen synthase activity MF
GO:0014823 response to activity BP
GO:0070542 response to fatty acid BP
GO:0071284 cellular response to lead ion BP

Sequence

>gi|6978483|ref|NP_037031.1| delta-aminolevulinic acid dehydratase [Rattus norvegicus]
MHHQSVLHSGYFHPLLRAWQTTPSTVSATNLIYPIFVTDVPDDVQPIASLPGVARYGVNQLEEMLRPLVE
AGLRCVLIFGVPSRVPKDEQGSAADSEDSPTIEAVRLLRKTFPTLLVACDVCLCPYTSHGHCGLLSENGA
FLAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKAALLKHGLGNRVSVMSYSAKFASCFYGPFRD
AAQSSPAFGDRRCYQLPPGARGLALRAVARDIQEGADILMVKPGLPYLDMVQEVKDKHPELPLAVYQVSG
EFAMLWHGAKAGAFDLRTAVLESMTAFRRAGADIIITYFAPQLLKWLKEE

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000020625
UniGene Rn.3941
PDB
RefSeq NP_037031.1
Pfam PF00490