GABA at

General Information (Source: NCBI Gene,UniProt)

Text mining Term GABA at
UniProt ID GABT_RAT
Name 4-aminobutyrate aminotransferase, brain isoform
GABA-T
4-aminobutyrate aminotransferase, liver isoform
L-AIBAT
GABA aminotransferase
4-aminobutyrate aminotransferase, mitochondrial
GABA transaminase
GABA-AT
(S)-3-amino-2-methylpropionate transaminase
Gamma-amino-N-butyrate transaminase
Gene Names Abat
Synonyms:Gabat
Taxonomy Rattus norvegicus

General annotation

Function Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Subcellular location Mitochondrion matrix.

Gene Ontology

GO:0032145 succinate-semialdehyde dehydrogenase binding MF
GO:0010039 response to iron ion BP
GO:0005759 mitochondrial matrix CC
GO:0045776 negative regulation of blood pressure BP
GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity MF
GO:0019717 synaptosome CC
GO:0001666 response to hypoxia BP
GO:0007620 copulation BP
GO:0048148 behavioral response to cocaine BP
GO:0030170 pyridoxal phosphate binding MF
GO:0042135 neurotransmitter catabolic process BP
GO:0045471 response to ethanol BP
GO:0042493 response to drug BP
GO:0003867 4-aminobutyrate transaminase activity MF
GO:0035094 response to nicotine BP
GO:0007626 locomotory behavior BP
GO:0032144 4-aminobutyrate transaminase complex CC
GO:0009450 gamma-aminobutyric acid catabolic process BP
GO:0042803 protein homodimerization activity MF

Sequence

>gi|13591900|ref|NP_112265.1| 4-aminobutyrate aminotransferase, mitochondrial [Rattus norvegicus]
MAFLLTTRRLVCSSQKNLHLFTPGSRYISQAAAKVDFEFDYDGPLMKTEVPGPRSQELMKQLNTIQNAEA
VHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYNHPALAKLVQQPQNASTFINRPALGILPPENFV
DKLRESLMSVAPKGMCQLITMACGSCSNENAFKTIFMWYRSKERGQRGFSKEELETCMVNQSPGCPDYSI
LSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVTDNQQEEARCLEEVEDLIVKY
RKKKRTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPA
DVMSFSKKMMTGGFFHKEEFRPSAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNVAHAGKTLLTGLL
DLQAQYPQFVSRVRGRGTFCSFDTPDKAIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLN
IFSGILADFK

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000003633
UniGene Rn.10090
PDB
RefSeq NP_112265.1
Pfam PF00202