c reactive protein

General Information (Source: NCBI Gene,UniProt)

Text mining Term c reactive protein
UniProt ID CRP_RAT
Name C-reactive protein
Gene Names Crp
Synonyms:Ptx1
Taxonomy Rattus norvegicus

General annotation

Function Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).
Subcellular location Secreted.

Gene Ontology

GO:0046872 metal ion binding MF
GO:0001666 response to hypoxia BP
GO:0005615 extracellular space CC
GO:0006958 complement activation, classical pathway BP
GO:0042803 protein homodimerization activity MF
GO:0006953 acute-phase response BP
GO:0051258 protein polymerization BP
GO:0010288 response to lead ion BP
GO:0015485 cholesterol binding MF

Sequence

>gi|8393197|ref|NP_058792.1| C-reactive protein precursor [Rattus norvegicus]
MEKLLWCLLITISFSQAFGHEDMSKQAFVFPGVSATAYVSLEAESKKPLEAFTVCLYAHADVSRSFSIFS
YATKTSFNEILLFWTRGQGFSIAVGGPEILFSASEIPEVPTHICATWESATGIVELWLDGKPRVRKSLQK
GYIVGTNASIILGQEQDSYGGGFDANQSLVGDIGDVNMWDFVLSPEQINAVYVGRVFSPNVLNWRALKYE
THGDVFIKPQLWPLTDCCES

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000000058
UniGene Rn.16463
PDB
RefSeq NP_058792.1
Pfam PF00354