apolipoprotein E

General Information (Source: NCBI Gene,UniProt)

Text mining Term apolipoprotein E
UniProt ID APOE_RAT
Name Apo-E
Apolipoprotein E
Gene Names Apoe
Taxonomy Rattus norvegicus

General annotation

Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Subcellular location Secreted.

Gene Ontology

GO:0043025 neuronal cell body CC
GO:0034364 high-density lipoprotein particle CC
GO:0045471 response to ethanol BP
GO:0031232 extrinsic to external side of plasma membrane CC
GO:0001540 beta-amyloid binding MF
GO:0030425 dendrite CC
GO:0014012 peripheral nervous system axon regeneration BP
GO:0005794 Golgi apparatus CC
GO:0007568 aging BP
GO:0008201 heparin binding MF
GO:0005543 phospholipid binding MF
GO:0006917 induction of apoptosis BP
GO:0071363 cellular response to growth factor stimulus BP
GO:0042627 chylomicron CC
GO:0034361 very-low-density lipoprotein particle CC
GO:0005770 late endosome CC

Sequence

>gi|162287337|ref|NP_620183.2| apolipoprotein E precursor [Rattus norvegicus]
MKALWALLLVPLLTGCLAEGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQEL
TVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQST
EELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAA
QPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVE
DMQRQWANLMEKIQASVATNSIASTTVPLENQ

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000041891
UniGene Rn.32351
PDB
RefSeq NP_620183.2
Pfam PF01442