osteonectin

General Information (Source: NCBI Gene,UniProt)

Text mining Term	osteonectin
UniProt ID	SPRC_RAT
Name	Basement-membrane protein 40 Osteonectin Secreted protein acidic and rich in cysteine BM-40 ON SPARC
Gene Names	Sparc
Taxonomy	Rattus norvegicus

General annotation

Function	Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Subcellular location	Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane (By similarity).

Gene Ontology

GO:0031988	membrane-bounded vesicle	CC
GO:0007165	signal transduction	BP
GO:0046686	response to cadmium ion	BP
GO:0005737	cytoplasm	CC
GO:0051591	response to cAMP	BP
GO:0042060	wound healing	BP
GO:0007507	heart development	BP
GO:0051384	response to glucocorticoid stimulus	BP
GO:0032496	response to lipopolysaccharide	BP
GO:0034097	response to cytokine stimulus	BP
GO:0005604	basement membrane	CC
GO:0030324	lung development	BP
GO:0043434	response to peptide hormone stimulus	BP
GO:0048839	inner ear development	BP
GO:0045471	response to ethanol	BP
GO:0010288	response to lead ion	BP
GO:0005509	calcium ion binding	MF
GO:0005634	nucleus	CC
GO:0033591	response to L-ascorbic acid	BP
GO:0001503	ossification	BP
GO:0051592	response to calcium ion	BP
GO:0005615	extracellular space	CC
GO:0009629	response to gravity	BP

Sequence

>gi|6981574|ref|NP_036788.1| SPARC precursor [Rattus norvegicus]
MRAWIFFLLCLAGRALAAPQTEAAEEMVAEETVVEETGLPVGANPVQVEMGEFEEGAEETVEEVVAENPC
QNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLH
LDYIGPCKYIAPCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGDHP
VELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIA
LEEWAGCFGIKEQDINKDLVI

Database Cross Reference

Ensembl Gene	ENSRNOT00000017486
UniGene	Rn.98989
PDB
RefSeq	NP_036788.1
Pfam	PF09289 PF10591 PF00050

PTID

osteonectin

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

Options for BLAST

Database:

Set subsequence:(optional):

Optional parameters:

Database Cross Reference