osteopontin

General Information (Source: NCBI Gene,UniProt)

Text mining Term osteopontin
UniProt ID OSTP_RAT
Name SPP-1
Osteopontin
Bone sialoprotein 1
Secreted phosphoprotein 1
Gene Names Spp1
Taxonomy Rattus norvegicus

General annotation

Function Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).
Subcellular location Secreted.

Gene Ontology

GO:0031214 biomineral tissue development BP
GO:0001649 osteoblast differentiation BP
GO:0006954 inflammatory response BP
GO:0048545 response to steroid hormone stimulus BP
GO:0005125 cytokine activity MF
GO:0045780 positive regulation of bone resorption BP
GO:0048685 negative regulation of collateral sprouting of intact axon in response to injury BP
GO:0042995 cell projection CC
GO:0007155 cell adhesion BP
GO:0005615 extracellular space CC
GO:0048471 perinuclear region of cytoplasm CC
GO:0031988 membrane-bounded vesicle CC

Sequence

>gi|145046230|ref|NP_037013.2| osteopontin precursor [Rattus norvegicus]
MRLAVVCFCLFGLASCLPVKVAEFGSSEEKAHYSKHSDAVATWLKPDPSQKQNLLAPQNSVSSEETDDFK
QETLPSNSNESHDHMDDDDDDDDDGDHAESEDSVNSDESDESHHSDESDESFTASTQADVLTPIAPTVDV
PDGRGDSLAYGLRSKSRSFPVSDEQYPDATDEDLTSRMKSQESDEAIKVIPVAQRLSVPSDQDSNGKTSH
ESSQLDEPSVETHSLEQSKEYKQRASHESTEQSDAIDSAEKPDAIDSAERSDAIDSQASSKASLEHQSHE
FHSHEDKLVLDPKSKEDDRYLKFRISHELESSSSEVN

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.8871
PDB
RefSeq NP_037013.2
Pfam PF00865