osteopontin

General Information (Source: NCBI Gene,UniProt)

Text mining Term osteopontin
UniProt ID OSTP_MOUSE
Name Early T-lymphocyte activation 1 protein
2AR
Secreted phosphoprotein 1
Minopontin
SPP-1
Osteopontin
Bone sialoprotein 1
Calcium oxalate crystal growth inhibitor protein
Gene Names Spp1
Taxonomy Mus musculus

General annotation

Function Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
Subcellular location Secreted.

Gene Ontology

GO:0005125 cytokine activity MF
GO:0005737 cytoplasm CC
GO:0031214 biomineral tissue development BP
GO:0045177 apical part of cell CC
GO:0001503 ossification BP
GO:0006916 anti-apoptosis BP
GO:0007155 cell adhesion BP
GO:0005615 extracellular space CC
GO:0050840 extracellular matrix binding MF
GO:0010811 positive regulation of cell-substrate adhesion BP

Sequence

>gi|323668271|ref|NP_001191162.1| osteopontin isoform 4 precursor [Mus musculus]
MRLAVICFCLFGIASSLPVKVTDSGSSEEKLYSLHPDPIATWLVPDPSQKQNLLAPQNAVSSEEKDDFKQ
ETLPSNSNESHDHMDDDDDDDDDDGDHAESEDSVDSDESDESHHSDESDETVTASTQADTFTPIVPTVDV
PNGRGDSLAYGLRSKSRSFQVSDEQYPDATDEDLTSHMKSGESKESLDVIPVAQLLSMPSDQDNNGKGSH
ESSQLDEPSLETHRLEHSKESQESADQSDVIDSQASSKASLEHQSHKFHSHKDKLVLDPKSKEDDRYLKF
RISHELESSSSEVN

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000112747
ENSMUST00000112748
ENSMUST00000031243
UniGene Mm.288474
PDB
RefSeq NP_001191162.1
NP_033289.2
Pfam PF00865