parathyroid hormone

General Information (Source: NCBI Gene,UniProt)

Text mining Term parathyroid hormone
UniProt ID PTHY_RAT
Name Parathyrin
PTH
Parathyroid hormone
Gene Names Pth
Taxonomy Rattus norvegicus

General annotation

Function PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
Subcellular location Secreted.

Gene Ontology

GO:0045725 positive regulation of glycogen biosynthetic process BP
GO:0045453 bone resorption BP
GO:0005179 hormone activity MF
GO:0006874 cellular calcium ion homeostasis BP
GO:0007189 activation of adenylate cyclase activity by G-protein signaling pathway BP
GO:0031856 parathyroid hormone receptor binding MF
GO:0007266 Rho protein signal transduction BP
GO:0046326 positive regulation of glucose import BP
GO:0001503 ossification BP
GO:0051428 peptide hormone receptor binding MF

Sequence

>gi|8394100|ref|NP_058740.1| parathyroid hormone precursor [Rattus norvegicus]
MMSASTMAKVMILMLAVCLLTQADGKPVKKRAVSEIQLMHNLGKHLASVERMQWLRKKLQDVHNFVSLGV
QMAAREGSYQRPTKKEENVLVDGNSKSLGEGDKADVDVLVKAKSQ

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Database Cross Reference

Ensembl Gene ENSRNOT00000019199
UniGene Rn.9768
PDB
RefSeq NP_058740.1
Pfam PF01279