eukaryotic translation initiation factor 4E

General Information (Source: NCBI Gene,UniProt)

Text mining Term eukaryotic translation initiation factor 4E
UniProt ID IF4E_RAT
Name eIF-4E
eIF-4F 25 kDa subunit
Eukaryotic translation initiation factor 4E
eIF4E
mRNA cap-binding protein
Gene Names Eif4e
Taxonomy Rattus norvegicus

General annotation

Function Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity). Recognizes and binds the 7- methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development.
Subcellular location

Gene Ontology

GO:0006417 regulation of translation BP
GO:0003743 translation initiation factor activity MF
GO:0031370 eukaryotic initiation factor 4G binding MF
GO:0016281 eukaryotic translation initiation factor 4F complex CC
GO:0005845 mRNA cap binding complex CC
GO:0030324 lung development BP

Sequence

>gi|16758870|ref|NP_446426.1| eukaryotic translation initiation factor 4E [Rattus norvegicus]
MATVEPETTPTTNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVE
DFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGE
SFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGST
TKNRFVV

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Database Cross Reference

Ensembl Gene ENSRNOT00000068613
UniGene Rn.11275
PDB
RefSeq NP_446426.1
Pfam PF01652