orphan nuclear receptor SHP

General Information (Source: NCBI Gene,UniProt)

Text mining Term orphan nuclear receptor SHP
UniProt ID NR0B2_RAT
Name Small heterodimer partner
Orphan nuclear receptor SHP
Nuclear receptor subfamily 0 group B member 2
Gene Names Nr0b2
Synonyms:Shp
Taxonomy Rattus norvegicus

General annotation

Function Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.
Subcellular location Cytoplasm (By similarity). Nucleus (Probable). Note=Colocalizes with NEUROD1 in the nucleus (By similarity).

Gene Ontology

GO:0042975 peroxisome proliferator activated receptor binding MF
GO:0000122 negative regulation of transcription from RNA polymerase II promoter BP
GO:0005737 cytoplasm CC
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity BP
GO:0043234 protein complex CC
GO:0046965 retinoid X receptor binding MF
GO:0003700 sequence-specific DNA binding transcription factor activity MF
GO:0003714 transcription corepressor activity MF
GO:0003677 DNA binding MF
GO:0046966 thyroid hormone receptor binding MF
GO:0006351 transcription, DNA-dependent BP
GO:0005634 nucleus CC
GO:0003707 steroid hormone receptor activity MF
GO:0009749 response to glucose stimulus BP
GO:0032403 protein complex binding MF
GO:0031100 organ regeneration BP
GO:0032024 positive regulation of insulin secretion BP

Sequence

>gi|16930821|ref|NP_476474.1| nuclear receptor subfamily 0 group B member 2 [Rattus norvegicus]
MSSSQSGVCPCQGSASHPTILYTLLSPGPRTRPMAPASRSHCLCQQHRPVRLCAPHRTCREALDVLGKTV
AFLRNLPSFCLLPHEDQRRLLEGCWGPLFLLGLAQDTVTFEVAEAPVPSILKKILLEEPNSGAQGAQPPD
PPQPSLAAVQWLQHCLESFWSLELGPKEYAYLKGTILFNPDVPGLHASCHIAHLQQEAHWALCEVLEPWY
PASQGRLARILLMASTLKNISCTLLVDLFFRPVIGDVDITELLEDMLLLR

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Database Cross Reference

Ensembl Gene ENSRNOT00000009683
UniGene Rn.10712
PDB 1YP0
1ZH7
1ZGY
RefSeq NP_476474.1
Pfam PF00104