paxillin

General Information (Source: NCBI Gene,UniProt)

Text mining Term paxillin
UniProt ID PAXI_RAT
Name Paxillin
Gene Names Pxn
Taxonomy Rattus norvegicus

General annotation

Function Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion) (By similarity).
Subcellular location Cytoplasm, cytoskeleton (By similarity). Cell junction, focal adhesion (By similarity).

Gene Ontology

GO:0005737 cytoplasm CC
GO:0019901 protein kinase binding MF
GO:0008270 zinc ion binding MF
GO:0005925 focal adhesion CC
GO:0005856 cytoskeleton CC
GO:0005178 integrin binding MF
GO:0007160 cell-matrix adhesion BP

Sequence

>gi|58865866|ref|NP_001012147.1| paxillin [Rattus norvegicus]
MDDLDALLADLESTTSHISKRPVFLSEEPPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTVLDPLDQWQ
PSGSRYAHQQPPSPSPIYSSSTKNSSASNPQDSVGSLCSRAGEEEHVYSFPNKQKSAEPSPTVMSSSLGS
NLSELDRLLLELNAVQRSPSGFSAGMVSVQASREPLGSWGTEGRAIILSPFFQDEAESSPPLPGALSPLY
GVPESNNLLGGKAGPLMKEKPKRNGGRGLEDVRPSVESLLDELENSVPSPVPAITVNQGEMSSPQRVTSS
QQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGLSKPGSQLDSMLGSLQSDLNKLGVATVAK
GVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHSLFSPRCYYCNGPIL
DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLW
HPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCL
KQLNKGTFKEQNDKPYCQSCFLKLFC

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000047466
UniGene Rn.75
PDB
RefSeq NP_001012147.1
Pfam PF00412