| Text mining Term | osteopontin |
|---|---|
| UniProt ID | OSTP_MOUSE |
| Name |
SPP-1 Minopontin Secreted phosphoprotein 1 Early T-lymphocyte activation 1 protein Calcium oxalate crystal growth inhibitor protein Osteopontin 2AR Bone sialoprotein 1 |
| Gene Names |
Spp1
|
| Taxonomy | Mus musculus |
| Function |
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. |
|---|---|
| Subcellular location |
Secreted. |
| GO:0005125 | cytokine activity | MF |
| GO:0045177 | apical part of cell | CC |
| GO:0031214 | biomineral tissue development | BP |
| GO:0001503 | ossification | BP |
| GO:0007155 | cell adhesion | BP |
| GO:0010811 | positive regulation of cell-substrate adhesion | BP |
| GO:0006916 | anti-apoptosis | BP |
| GO:0050840 | extracellular matrix binding | MF |
| GO:0005615 | extracellular space | CC |
| GO:0005737 | cytoplasm | CC |
>gi|323668271|ref|NP_001191162.1| osteopontin isoform 4 precursor [Mus musculus] MRLAVICFCLFGIASSLPVKVTDSGSSEEKLYSLHPDPIATWLVPDPSQKQNLLAPQNAVSSEEKDDFKQ ETLPSNSNESHDHMDDDDDDDDDDGDHAESEDSVDSDESDESHHSDESDETVTASTQADTFTPIVPTVDV PNGRGDSLAYGLRSKSRSFQVSDEQYPDATDEDLTSHMKSGESKESLDVIPVAQLLSMPSDQDNNGKGSH ESSQLDEPSLETHRLEHSKESQESADQSDVIDSQASSKASLEHQSHKFHSHKDKLVLDPKSKEDDRYLKF RISHELESSSSEVN |
| Ensembl Gene |
ENSMUST00000112747 ENSMUST00000031243 ENSMUST00000112748 |
|---|---|
| UniGene |
Mm.288474 |
| PDB | |
| RefSeq |
NP_033289.2 NP_001191162.1 |
| Pfam |
PF00865 |