apolipoprotein A I

General Information (Source: NCBI Gene,UniProt)

Text mining Term apolipoprotein A I
UniProt ID APOA1_RAT
Name Apolipoprotein A-I
Apo-AI
Apolipoprotein A1
ApoA-I
Gene Names Apoa1
Taxonomy Rattus norvegicus

General annotation

Function Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Subcellular location Secreted.

Gene Ontology

GO:0008289 lipid binding MF
GO:0007584 response to nutrient BP
GO:0034364 high-density lipoprotein particle CC
GO:0031100 organ regeneration BP
GO:0042493 response to drug BP
GO:0005634 nucleus CC
GO:0043627 response to estrogen stimulus BP
GO:0060192 negative regulation of lipase activity BP
GO:0008203 cholesterol metabolic process BP
GO:0055102 lipase inhibitor activity MF
GO:0014012 peripheral nervous system axon regeneration BP
GO:0042157 lipoprotein metabolic process BP
GO:0005548 phospholipid transporter activity MF
GO:0017127 cholesterol transporter activity MF

Sequence

>gi|6978515|ref|NP_036870.1| apolipoprotein A-I preproprotein [Rattus norvegicus]
MKAAVLAVALVFLTGCQAWEFWQQDEPQSQWDRVKDFATVYVDAVKDSGRDYVSQFESSTLGKQLNLNLL
DNWDTLGSTVGRLQEQLGPVTQEFWANLEKETDWLRNEMNKDLENVKQKMQPHLDEFQEKWNEEVEAYRQ
KLEPLGTELHKNAKEMQRHLKVVAEEFRDRMRVNADALRAKFGLYSDQMRENLAQRLTEIKNHPTLIEYH
TKASDHLKTLGEKAKPALDDLGQGLMPVLEAWKAKIMSMIDEAKKKLNA

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.10308
PDB
RefSeq NP_036870.1
Pfam PF01442