| Text mining Term | osteoprotegerin |
|---|---|
| UniProt ID | TR11B_RAT |
| Name |
Tumor necrosis factor receptor superfamily member 11B Osteoprotegerin |
| Gene Names |
Tnfrsf11b
Synonyms:Opg |
| Taxonomy | Rattus norvegicus |
| Function |
Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity). |
|---|---|
| Subcellular location |
Secreted (By similarity). |
| GO:0042493 | response to drug | BP |
| GO:0046685 | response to arsenic-containing substance | BP |
| GO:0005615 | extracellular space | CC |
| GO:0007165 | signal transduction | BP |
| GO:0005125 | cytokine activity | MF |
| GO:0045779 | negative regulation of bone resorption | BP |
| GO:0007584 | response to nutrient | BP |
| GO:0032026 | response to magnesium ion | BP |
| GO:0045671 | negative regulation of osteoclast differentiation | BP |
| GO:0042489 | negative regulation of odontogenesis of dentin-containing tooth | BP |
| GO:0043627 | response to estrogen stimulus | BP |
| GO:0006915 | apoptotic process | BP |
>gi|6981306|ref|NP_037002.1| tumor necrosis factor receptor superfamily member 11B precursor [Rattus norvegicus] MNKWLCCALLVFLDIIEWTTQETFPPKYLHYDPETGRQLLCDKCAPGTYLKQHCTVRRKTLCVPCPDYSY TDSWHTSDECVYCSPVCKELQTVKQECNRTHNRVCECEEGRYLELEFCLKHRSCPPGLGVLQAGTPERNT VCKRCPDGFFSGETSSKAPCRKHTNCSSLGLLLIQKGNATHDNVCSGNREATQNCGIDVTLCEEAFFRFA VPTKIIPNWLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDLCESS VQRHIGHANLTTEQLRILMESLPGKKISPDEIERTRKTCKPSEQLLKLLSLWRIKNGDQDTLKGLMYALK HLKAYHFPKTVTHSLRKTIRFLHSFTMYRLYQKLFLEMIGNQVQSVKISCL |
| Ensembl Gene |
ENSRNOT00000011344 |
|---|---|
| UniGene |
Rn.202973 |
| PDB | |
| RefSeq |
NP_037002.1 |
| Pfam |
PF00020 PF00531 |