| Text mining Term | osteoprotegerin |
|---|---|
| UniProt ID | TR11B_RAT |
| Name |
Tumor necrosis factor receptor superfamily member 11B Osteoprotegerin |
| Gene Names |
Tnfrsf11b
Synonyms:Opg |
| Taxonomy | Rattus norvegicus |
| Function |
Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity). |
|---|---|
| Subcellular location |
Secreted (By similarity). |
| GO:0046685 | response to arsenic-containing substance | BP |
| GO:0042489 | negative regulation of odontogenesis of dentin-containing tooth | BP |
| GO:0007165 | signal transduction | BP |
| GO:0005615 | extracellular space | CC |
| GO:0045671 | negative regulation of osteoclast differentiation | BP |
| GO:0006915 | apoptotic process | BP |
| GO:0007584 | response to nutrient | BP |
| GO:0005125 | cytokine activity | MF |
| GO:0042493 | response to drug | BP |
| GO:0043627 | response to estrogen stimulus | BP |
| GO:0045779 | negative regulation of bone resorption | BP |
| GO:0032026 | response to magnesium ion | BP |
>gi|6981306|ref|NP_037002.1| tumor necrosis factor receptor superfamily member 11B precursor [Rattus norvegicus] MNKWLCCALLVFLDIIEWTTQETFPPKYLHYDPETGRQLLCDKCAPGTYLKQHCTVRRKTLCVPCPDYSY TDSWHTSDECVYCSPVCKELQTVKQECNRTHNRVCECEEGRYLELEFCLKHRSCPPGLGVLQAGTPERNT VCKRCPDGFFSGETSSKAPCRKHTNCSSLGLLLIQKGNATHDNVCSGNREATQNCGIDVTLCEEAFFRFA VPTKIIPNWLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDLCESS VQRHIGHANLTTEQLRILMESLPGKKISPDEIERTRKTCKPSEQLLKLLSLWRIKNGDQDTLKGLMYALK HLKAYHFPKTVTHSLRKTIRFLHSFTMYRLYQKLFLEMIGNQVQSVKISCL |
| Ensembl Gene |
ENSRNOT00000011344 |
|---|---|
| UniGene |
Rn.202973 |
| PDB | |
| RefSeq |
NP_037002.1 |
| Pfam |
PF00020 PF00531 |