NaPi 2a

General Information (Source: NCBI Gene,UniProt)

Text mining Term NaPi 2a
UniProt ID NPT2A_RAT
Name Na(+)-dependent phosphate cotransporter 2A
Sodium/phosphate cotransporter 2A
Sodium-dependent phosphate transport protein 2A
Sodium-phosphate transport protein 2A
Solute carrier family 34 member 1
Na(+)/Pi cotransporter 2A
NaPi-2a
Gene Names Slc34a1
Synonyms:Slc17a2
Taxonomy Rattus norvegicus

General annotation

Function May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.
Subcellular location Membrane; Multi-pass membrane protein.

Gene Ontology

GO:0016021 integral to membrane CC
GO:0015293 symporter activity MF
GO:0006814 sodium ion transport BP
GO:0032026 response to magnesium ion BP
GO:0031526 brush border membrane CC
GO:0015321 sodium-dependent phosphate transmembrane transporter activity MF

Sequence

>gi|6981544|ref|NP_037162.1| sodium-dependent phosphate transport protein 2A [Rattus norvegicus]
MMSYSERLGGPAVSPLPVRGRHMVHGAAFAYVPSPQVLHRIPGTTTYAISSLSPVALTEHSCPYGEVLEC
HDPLPAKLAQEEEQKPEPRLSQKLAQVGTKLLKVPLMLGFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDN
AILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDR
TDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKVITEPFTKLIIQ
LDKSVITSIAVGDESLRNHSLIRIWCQPETKEASTSMSRVEAIGSLANTTMEKCNHIFVDTGLPDLAVGL
ILLAGSLVVLCTCLILLVKMLNSLLKGQVANVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVF
TSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLP
CTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQAMVGVGTPFGALLAFVVLVNVLQ
SRSPGHLPKWLQTWDFLPRWMHSLQPLDGLITRATLCYARPEPRSPQLPPRVFLEELPPATPSPRLALPA
HHNATRL

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Database Cross Reference

Ensembl Gene ENSRNOT00000033749
UniGene Rn.92022
PDB
RefSeq NP_037162.1
Pfam PF02690