fibroblast growth factor 23

General Information (Source: NCBI Gene,UniProt)

Text mining Term fibroblast growth factor 23
UniProt ID FGF23_RAT
Name FGF-23
Fibroblast growth factor 23
Gene Names Fgf23
Taxonomy Rattus norvegicus

General annotation

Function Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL.
Subcellular location Secreted (By similarity). Note=Secretion is dependent on O-glycosylation (By similarity).

Gene Ontology

GO:0046888 negative regulation of hormone secretion BP
GO:0030154 cell differentiation BP
GO:0006796 phosphate-containing compound metabolic process BP
GO:0008083 growth factor activity MF

Sequence

>gi|18543369|ref|NP_570110.1| fibroblast growth factor 23 precursor [Rattus norvegicus]
MLGACLRLLVGALCTVCSLGTARAYSDTSPLLGSNWGSLTHLYTATARNSYHLQIHRDGHVDGTPHQTIY
SALMITSEDAGSVVIIGAMTRRFLCMDLRGNIFGSYHFSPENCRFRQWTLENGYDVYLSPKHHYLVSLGR
SKRIFQPGTNPPPFSQFLARRNEVPLLHFYTARPRRHTRSAEDPPERDPLNVLKPRPRATPIPVSCSREL
PSAEEGGPAASDPLGVLRRGRGDARRGAGGTDRCRPFPRFV

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Database Cross Reference

Ensembl Gene ENSRNOT00000026888
UniGene Rn.154421
PDB
RefSeq NP_570110.1
Pfam PF00167