Fetuin A

General Information (Source: NCBI Gene,UniProt)

Text mining Term Fetuin A
UniProt ID FETUA_RAT
Name 59 kDa bone sialic acid-containing protein
Alpha-2-HS-glycoprotein
Fetuin-A
BSP
Glycoprotein PP63
Gene Names Ahsg
Synonyms:Fetua
Taxonomy Rattus norvegicus

General annotation

Function Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells.
Subcellular location Secreted.

Gene Ontology

GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity MF
GO:0004869 cysteine-type endopeptidase inhibitor activity MF
GO:0031100 organ regeneration BP
GO:0045780 positive regulation of bone resorption BP
GO:0032869 cellular response to insulin stimulus BP
GO:0005615 extracellular space CC
GO:0043234 protein complex CC
GO:0031012 extracellular matrix CC
GO:0030308 negative regulation of cell growth BP
GO:0050766 positive regulation of phagocytosis BP
GO:0050727 regulation of inflammatory response BP
GO:0030502 negative regulation of bone mineralization BP
GO:0006953 acute-phase response BP
GO:0008584 male gonad development BP
GO:0046627 negative regulation of insulin receptor signaling pathway BP
GO:0021987 cerebral cortex development BP

Sequence

>gi|6978477|ref|NP_037030.1| alpha-2-HS-glycoprotein precursor [Rattus norvegicus]
MKSLVLLLCFAQLWSCQSAPQGAGLGFRELACDDPETEHVALIAVHYLNKHLLQGFRQILNQIDKVKVWS
RRPFGQVYELEIDTLETTCHALDPTPLANCSVRQQAEHAVEGDCDFHILKQDGQFRVLHAQCHSTPDSAE
DVRKFCPRCPILIRFNDTNVVHTVKTALAAFNAQNNGTYFKLVEISRAQNVPFPVSTLVEFVIAATDCTG
QEVTDPAKCNLLAEKQYGFCKATLIHRLGGEEVSVACKLFQTQPQPANANPAGPAPTVGQAAPVAPPAGP
PESVVVGPVAVPLGLPDHRTHHDLRHAFSPVASVESASGEVLHSPKVGQPGDAGAAGPVAPLCPGRVRYF
KI

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.32083
PDB
RefSeq NP_037030.1
Pfam PF00031