interleukin 15

General Information (Source: NCBI Gene,UniProt)

Text mining Term interleukin 15
UniProt ID IL15_RAT
Name Interleukin-15
IL-15
Gene Names Il15
Taxonomy Rattus norvegicus

General annotation

Function Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha (By similarity).
Subcellular location Secreted.

Gene Ontology

GO:0006954 inflammatory response BP
GO:0048662 negative regulation of smooth muscle cell proliferation BP
GO:0006955 immune response BP
GO:0001525 angiogenesis BP
GO:0014732 skeletal muscle atrophy BP
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein BP
GO:0030212 hyaluronan metabolic process BP
GO:0005125 cytokine activity MF
GO:0005615 extracellular space CC
GO:0071305 cellular response to vitamin D BP
GO:0005126 cytokine receptor binding MF
GO:0007568 aging BP

Sequence

>gi|6981092|ref|NP_037261.1| interleukin-15 precursor [Rattus norvegicus]
MKILKPYMRNTSILYYLCFLLNSHFLTEAGIHVFILGCVSVGLPKTEANWIDVRYDLEKIESLIQFIHID
TTLYTDSDFHPSCKVTAMNCFLLELQVILHEYSNMTLNETVRNVLYLANSTLSSNKNVIESGCKECEELE
ERNFTEFLQSFIHIVQMFINTS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000004590
UniGene Rn.2490
PDB
RefSeq NP_037261.1
Pfam PF02372