interleukin 2

General Information (Source: NCBI Gene,UniProt)

Text mining Term interleukin 2
UniProt ID IL2_RAT
Name T-cell growth factor
IL-2
Interleukin-2
TCGF
Gene Names Il2
Taxonomy Rattus norvegicus

General annotation

Function Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells.
Subcellular location Secreted.

Gene Ontology

GO:0060999 positive regulation of dendritic spine development BP
GO:0001933 negative regulation of protein phosphorylation BP
GO:0005125 cytokine activity MF
GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway BP
GO:0045822 negative regulation of heart contraction BP
GO:0008083 growth factor activity MF
GO:0045591 positive regulation of regulatory T cell differentiation BP
GO:0006955 immune response BP
GO:0031851 kappa-type opioid receptor binding MF
GO:0007204 elevation of cytosolic calcium ion concentration BP
GO:0043208 glycosphingolipid binding MF
GO:0005134 interleukin-2 receptor binding MF
GO:0030246 carbohydrate binding MF
GO:0005615 extracellular space CC

Sequence

>gi|16758692|ref|NP_446288.1| interleukin-2 precursor [Rattus norvegicus]
MYSMQLASCVALTLVLLVNSAPTSSPAKETQQHLEQLLLDLQVLLRGIDNYKNLKLPMMLTFKFYLPKQA
TELKHLQCLENELGALQRVLDLTQSKSFHLEDAGNFISNIRVTVVKLKGSENKFECQFDDEPATVVEFLR
RWIAICQSIISTMTQ

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000023327
UniGene Rn.9871
PDB
RefSeq NP_446288.1
Pfam PF00715