| Text mining Term | 5 lipoxygenase |
|---|---|
| UniProt ID | LOX5_MOUSE |
| Name |
5-LO Arachidonate 5-lipoxygenase 5-lipoxygenase |
| Gene Names |
Alox5
|
| Taxonomy | Mus musculus |
| Function |
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. |
|---|---|
| Subcellular location |
Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein (By similarity). Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association (By similarity). |
| GO:0016165 | lipoxygenase activity | MF |
| GO:0031965 | nuclear membrane | CC |
| GO:0005506 | iron ion binding | MF |
| GO:0002540 | leukotriene production involved in inflammatory response | BP |
| GO:0005641 | nuclear envelope lumen | CC |
| GO:0019370 | leukotriene biosynthetic process | BP |
| GO:0005829 | cytosol | CC |
| GO:0016363 | nuclear matrix | CC |
| GO:0004051 | arachidonate 5-lipoxygenase activity | MF |
>gi|62526037|ref|NP_033792.1| arachidonate 5-lipoxygenase [Mus musculus] MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGAVDSYDVTVDEELGEIYLVKI EKRKYWLHDDWYLKYITLKTPHGDYIEFPCYRWITGEGEIVLRDGRAKLARDDQIHILKQHRRKELEARQ KQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEK IFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTALPPKLPVTTEMVECSLERQLSLEQEVQEG NIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGESNPIFLPTDSKYDWLL AKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLICEYG LFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDSTEDIPFYFYRDDGLLVWEAIQSFTMEVV SIYYENDQVVEEDQELQDFVKDVYVYGMRGKKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYD WCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKP VKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI |
| Ensembl Gene |
ENSMUST00000026795 |
|---|---|
| UniGene |
Mm.41072 |
| PDB | |
| RefSeq |
NP_033792.1 |
| Pfam |
PF01477 PF00305 |