5 lipoxygenase

General Information (Source: NCBI Gene,UniProt)

Text mining Term 5 lipoxygenase
UniProt ID LOX5_RAT
Name Arachidonate 5-lipoxygenase
5-lipoxygenase
5-LO
Gene Names Alox5
Taxonomy Rattus norvegicus

General annotation

Function Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Subcellular location Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-271. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.

Gene Ontology

GO:0019369 arachidonic acid metabolic process BP
GO:0016165 lipoxygenase activity MF
GO:0019233 sensory perception of pain BP
GO:0016363 nuclear matrix CC
GO:0045907 positive regulation of vasoconstriction BP
GO:0055093 response to hyperoxia BP
GO:0002526 acute inflammatory response BP
GO:0019372 lipoxygenase pathway BP
GO:0042383 sarcolemma CC
GO:0005625 soluble fraction CC
GO:0031965 nuclear membrane CC
GO:0005641 nuclear envelope lumen CC
GO:0007584 response to nutrient BP
GO:0019370 leukotriene biosynthetic process BP
GO:0005829 cytosol CC
GO:0004051 arachidonate 5-lipoxygenase activity MF
GO:0030425 dendrite CC
GO:0005515 protein binding MF
GO:0005506 iron ion binding MF

Sequence

>gi|6978493|ref|NP_036954.1| arachidonate 5-lipoxygenase [Rattus norvegicus]
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDEELGEIYLVKI
EKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLARDDQIHILKQHRRKELETRQK
QYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKI
FVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGN
IFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLA
KIWVRSSDFHIHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEAIQSFTTEVVS
IYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDW
CSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPV
KEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRFQTV

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.9662
PDB
RefSeq NP_036954.1
Pfam PF01477
PF00305