growth arrest specific protein 6

General Information (Source: NCBI Gene,UniProt)

Text mining Term growth arrest specific protein 6
UniProt ID GAS6_MOUSE
Name Growth arrest-specific protein 6
GAS-6
AXL receptor tyrosine kinase ligand
Gene Names Gas6
Taxonomy Mus musculus

General annotation

Function Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
Subcellular location Secreted (By similarity).

Gene Ontology

GO:0031589 cell-substrate adhesion BP
GO:0043277 apoptotic cell clearance BP
GO:0005615 extracellular space CC
GO:0048018 receptor agonist activity MF
GO:0007596 blood coagulation BP
GO:0010934 macrophage cytokine production BP
GO:0007167 enzyme linked receptor protein signaling pathway BP
GO:0040008 regulation of growth BP
GO:0043066 negative regulation of apoptotic process BP
GO:0071363 cellular response to growth factor stimulus BP
GO:0005509 calcium ion binding MF
GO:0009267 cellular response to starvation BP
GO:0001764 neuron migration BP
GO:0043491 protein kinase B signaling cascade BP

Sequence

>gi|145301603|ref|NP_062394.2| growth arrest-specific protein 6 precursor [Mus musculus]
MPPPPGPAAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKE
EAREVFENDPETEYFYPRYQECMRKYGRPEEKNPDFAKCVQNLPDQCTPNPCDKKGTHICQDLMGNFFCV
CTDGWGGRLCDKDVNECVQKNGGCSQVCHNKPGSFQCACHSGFSLASDGQTCQDIDECTDSDTCGDARCK
NLPGSYSCLCDEGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCDGRGGLKLSPDMDTCEDILPC
VPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAG
RLELQLRYNGVGRITSSGPTINHGMWQTISVEELERNLVIKVNKDAVMKIAVAGELFQLERGLYHLNLTV
GGIPFKESELVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNGFATYRLNYT
RTSLDVGTETTWEVKVVARIRPATDTGVLLALVGDDDVVPISVALVDYHSTKKLKKQLVVLAVEDVALAL
MEIKVCDSQEHTVTVSLREGEATLEVDGTKGQSEVSTAQLQERLDTLKTHLQGSVHTYVGGLPEVSVISA
PVTAFYRGCMTLEVNGKILDLDTASYKHSDITSHSCPPVEHATP

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000033828
UniGene Mm.3982
PDB
RefSeq NP_062394.2
Pfam PF00594
PF02210