p38

General Information (Source: NCBI Gene,UniProt)

Text mining Term p38
UniProt ID CRK_RAT
Name Proto-oncogene c-Crk
p38
Adapter molecule crk
Gene Names Crk
Synonyms:Crko
Taxonomy Rattus norvegicus

General annotation

Function The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling (By similarity).
Subcellular location Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion.

Gene Ontology

GO:0032956 regulation of actin cytoskeleton organization BP
GO:0007257 activation of JUN kinase activity BP
GO:0035020 regulation of Rac protein signal transduction BP
GO:0051270 regulation of cellular component movement BP
GO:0032319 regulation of Rho GTPase activity BP
GO:0005886 plasma membrane CC
GO:0048013 ephrin receptor signaling pathway BP
GO:0005829 cytosol CC

Sequence

>gi|9506515|ref|NP_062175.1| adapter molecule crk [Rattus norvegicus]
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPP
VPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRAL
FDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHP
QPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECN
GKRGHFPFTHVRLLDQQNPEEDFS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000006407
UniGene Rn.96136
PDB
RefSeq NP_062175.1
Pfam PF00018
PF00017
PF07653