Raf 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term Raf 1
UniProt ID RAF1_RAT
Name Raf-1
cRaf
RAF proto-oncogene serine/threonine-protein kinase
Proto-oncogene c-RAF
Gene Names Raf1
Synonyms:Raf
Taxonomy Rattus norvegicus

General annotation

Function Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3/MST2 (By similarity).
Subcellular location Cytoplasm. Cell membrane. Note=Colocalizes with RGS14 and BRAF in both the cytoplasm and membranes.

Gene Ontology

GO:0031434 mitogen-activated protein kinase kinase binding MF
GO:0046982 protein heterodimerization activity MF
GO:0005626 insoluble fraction CC
GO:0005886 plasma membrane CC
GO:0007507 heart development BP
GO:0000165 MAPKKK cascade BP
GO:0004709 MAP kinase kinase kinase activity MF
GO:0005829 cytosol CC
GO:0046872 metal ion binding MF
GO:0001666 response to hypoxia BP
GO:0005524 ATP binding MF

Sequence

>gi|6981458|ref|NP_036771.1| RAF proto-oncogene serine/threonine-protein kinase [Rattus norvegicus]
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTVV
NVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHN
FARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTASDSGVPAPP
SFTMRRMRESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVM
LSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA
TVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFM
VGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAH
TEDINACTLTTSPRLPVF

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000013831
UniGene Rn.33262
PDB 1RRB
RefSeq NP_036771.1
Pfam PF02196
PF07714
PF00130