interleukin 1 alpha

General Information (Source: NCBI Gene,UniProt)

Text mining Term interleukin 1 alpha
UniProt ID Q3U0Y6_MOUSE
Name Interleukin 1 alpha, isoform CRA_b
Interleukin 1 alpha
Gene Names Il1a
Taxonomy Mus musculus

General annotation

Function Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).
Subcellular location

Gene Ontology

GO:0005149 interleukin-1 receptor binding MF
GO:0005615 extracellular space CC
GO:0005125 cytokine activity MF
GO:0051781 positive regulation of cell division BP
GO:0001660 fever generation BP
GO:0006955 immune response BP

Sequence

>gi|47059075|ref|NP_034684.2| interleukin-1 alpha precursor [Mus musculus]
MAKVPDLFEDLKNCYSENEDYSSAIDHLSLNQKSFYDASYGSLHETCTDQFVSLRTSETSKMSNFTFKES
RVTVSATSSNGKILKKRRLSFSETFTEDDLQSITHDLEETIQPRSAPYTYQSDLRYKLMKLVRQKFVMND
SLNQTIYQDVDKHYLSTTWLNDLQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGEDQPVLLKEL
PETPKLITGSETDLIFFWKSINSKNYFTSAAYPELFIATKEQSRVHLARGLPSMTDFQIS

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Mm.15534
PDB
RefSeq NP_034684.2
Pfam PF02394
PF00340