glucocorticoid receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term glucocorticoid receptor
UniProt ID GCR_RAT
Name GR
Nuclear receptor subfamily 3 group C member 1
Glucocorticoid receptor
Gene Names Nr3c1
Synonyms:Grl
Taxonomy Rattus norvegicus

General annotation

Function Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity).
Subcellular location Cytoplasm (By similarity). Nucleus (By similarity). Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding (By similarity).

Gene Ontology

GO:0014823 response to activity BP
GO:0003713 transcription coactivator activity MF
GO:0045944 positive regulation of transcription from RNA polymerase II promoter BP
GO:0046685 response to arsenic-containing substance BP
GO:0030544 Hsp70 protein binding MF
GO:0005634 nucleus CC
GO:0007420 brain development BP
GO:0007568 aging BP
GO:0051412 response to corticosterone stimulus BP
GO:0046689 response to mercury ion BP
GO:0004883 glucocorticoid receptor activity MF
GO:0043565 sequence-specific DNA binding MF
GO:0014069 postsynaptic density CC
GO:0043234 protein complex CC
GO:0051879 Hsp90 protein binding MF
GO:0030324 lung development BP
GO:0009314 response to radiation BP
GO:0071549 cellular response to dexamethasone stimulus BP
GO:0014889 muscle atrophy BP
GO:0005496 steroid binding MF
GO:0048096 chromatin-mediated maintenance of transcription BP
GO:0003682 chromatin binding MF
GO:0042127 regulation of cell proliferation BP
GO:0007623 circadian rhythm BP
GO:0043116 negative regulation of vascular permeability BP
GO:0042803 protein homodimerization activity MF
GO:0014049 positive regulation of glutamate secretion BP
GO:0003700 sequence-specific DNA binding transcription factor activity MF
GO:0046982 protein heterodimerization activity MF
GO:0003690 double-stranded DNA binding MF
GO:0008270 zinc ion binding MF
GO:0071286 cellular response to magnesium ion BP
GO:0032868 response to insulin stimulus BP
GO:0019717 synaptosome CC
GO:0006916 anti-apoptosis BP
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway BP
GO:0006351 transcription, DNA-dependent BP
GO:0030971 receptor tyrosine kinase binding MF

Sequence

>gi|158303300|ref|NP_036708.2| glucocorticoid receptor [Rattus norvegicus]
MDSKESLAPPGRDEVPGSLLGQGRGSVMDFYKSLRGGATVKVSASSPSVAAASQADSKQQRILLDFSKGS
TSNVQQRQQQQQQQQQQQQQQQQQQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFR
LLEESIANLNRSTSVPENPKSSTSATGCATPTEKEFPKTHSDASSEQQNRKSQTGTNGGSVKLYPTDQST
FDLLKDLEFSAGSPGKDTNESPWRSDLLIDENLLSPLAGEDDPFLLEGDTNEDCKPLILPDTKPKIKDTG
DTILSSPSSVALPQVKTEKDDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQM
YHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDSLTSLGALNFPGRSVFSNGYSSPGMRPD
VSSPPSSSSAATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKN
CPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENPNKTIVPAALPQLTPTLVSLLEVIEPEV
LYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSY
RQSSGNLLCFAPDLIINEQRMSLPCMYDQCKHMLFVSSELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQ
ELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLTYCFQTFLDKTMSIEFPEML
AEIITNQIPKYSNGNIKKLLFHQK

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.90070
PDB 3G9J
3FYL
3G8X
3G6P
3G9P
3G8U
1R4O
3G6Q
3G99
1GDC
1R4R
1LAT
2GDA
3G9O
3G9M
3G6R
3G6U
3G97
1GLU
1RGD
3G9I
3G6T
RefSeq NP_036708.2
Pfam PF00105
PF00104
PF02155