epidermal growth factor

General Information (Source: NCBI Gene,UniProt)

Text mining Term epidermal growth factor
UniProt ID EGF_RAT
Name Pro-epidermal growth factor
Epidermal growth factor
EGF
Gene Names Egf
Taxonomy Rattus norvegicus

General annotation

Function EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
Subcellular location Membrane; Single-pass type I membrane protein.

Gene Ontology

GO:0007173 epidermal growth factor receptor signaling pathway BP
GO:0007262 STAT protein import into nucleus BP
GO:0050708 regulation of protein secretion BP
GO:0008083 growth factor activity MF
GO:0016021 integral to membrane CC
GO:0005625 soluble fraction CC
GO:0005154 epidermal growth factor receptor binding MF
GO:0005509 calcium ion binding MF
GO:0043388 positive regulation of DNA binding BP

Sequence

>gi|6978797|ref|NP_036974.1| pro-epidermal growth factor precursor [Rattus norvegicus]
MLFSLTFLSVFLKITVLSVTAQQTRNCQSGPLERSGTTTYAAAGPPRFLIFLQGNSIFRINTDGTNHQQL
VVDAGVSVVMDFHYKEERLYWVDLERQLLQRVFFNGSGQETVCKVDKNVSGLAINWIDGEILRTDRWKGV
ITVTDMNGNNSRVLLSSLKRPANILVDPTERLIFWSSVVTGNLHRADLGGMDVKTLLEAPERISVLILDI
LDKRLFWAQDGREGSHGYIHSCDYNGGSIHHIRHQARHDLLTMAIFGDKILYSALKEKAIWIADKHTGKN
VVRVNLDPASVPPRELRVVHLHAQPGTENRAQASDSERCKQRRGQCLYSLSERDPNSDSSACAEGYTLSR
DRKYCEDVNECALQNHGCTLGCENIPGSYYCTCPTGFVLLPDGKRCHELVACPGNRSECSHDCILTSDGP
LCICPAGSVLGKDGKTCTGCSFSDNGGCSQICLPLSLASWECDCFPGYDLQLDRKSCAASMGPQPFLLFA
NSQDIRHMHFDGTDYKTLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANLDGSQRERRITEGVDTPE
GLAVDWIGRRIYWTDSGKSVIEGSDLSGKHHQIIIKESISRPRGIAVHPKARRLFWTDTGMSPRIESSSL
QGSDRTLIASSNLLEPSGIAIDYLTDTLYWCDTKLSVIEMADLDGSKRRRLTQNDVGHPFSLAVFEDHVW
FSDWAIPSVIRVNKRTGQNRVRLRGSMLKPSSLVVVHPLAKPGADPCLHRNGGCEHICQESLGTAQCLCR
EGFVKAPDGKMCLTRKDDQILAGDNADLSKEVASLDNSPKAYVPDDDRTESSTLVAEIMVSGLNYEDDCG
PGGCGSHAHCISEGEAAVCQCLKGFAGDGNLCSDIDECELGSSDCPPTSSRCINTEGGYVCQCSEGYEGD
GIYCLDVDECQQGSHGCSENATCTNTEGGYNCTCAGCPSAPGLPCPDSTSPSLLGKDGCHWVRNSNTGCP
PSYDGYCLNGGVCMYVESVDRYVCNCVIGYIGERCQHRDLRWWKLRHADYGQRHDITVVSVCVVALALLL
LLGMWGTYYYRTRKQLSESSKKPSEESSSNVSSNGPDSSGAGVSSGPQPWFVVLEEHQQPKNGRLPAAGT
NGAVVEAGLSSSL

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.6075
PDB
RefSeq NP_036974.1
Pfam PF07645
PF00058