tumor necrosis factor

General Information (Source: NCBI Gene,UniProt)

Text mining Term tumor necrosis factor
UniProt ID TNFA_RAT
Name Tumor necrosis factor, soluble form
Tumor necrosis factor ligand superfamily member 2
Tumor necrosis factor
Tumor necrosis factor, membrane form
TNF-alpha
TNF-a
Cachectin
Gene Names Tnf
Taxonomy Rattus norvegicus

General annotation

Function Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Subcellular location Cell membrane; Single-pass type II membrane protein (By similarity). Tumor necrosis factor, soluble form: Secreted (By similarity).

Gene Ontology

GO:0045840 positive regulation of mitosis BP
GO:0014823 response to activity BP
GO:0001666 response to hypoxia BP
GO:0008285 negative regulation of cell proliferation BP
GO:0009612 response to mechanical stimulus BP
GO:0005615 extracellular space CC
GO:0050806 positive regulation of synaptic transmission BP
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade BP
GO:0005125 cytokine activity MF
GO:0003009 skeletal muscle contraction BP
GO:0042493 response to drug BP
GO:0046325 negative regulation of glucose import BP
GO:0001775 cell activation BP
GO:0019722 calcium-mediated signaling BP
GO:0005164 tumor necrosis factor receptor binding MF
GO:0043525 positive regulation of neuron apoptosis BP
GO:0002037 negative regulation of L-glutamate transport BP

Sequence

>gi|6981662|ref|NP_036807.1| tumor necrosis factor [Rattus norvegicus]
MSTESMIRDVELAEEALPKKMGGLQNSRRCLCLSLFSFLLVAGATTLFCLLNFGVIGPNKEEKFPNGLPL
ISSMAQTLTLRSSSQNSSDKPVAHVVANHQAEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLIYSQ
VLFKGQGCPDYVLLTHTVSRFAISYQEKVSLLSAIKSPCPKDTPEGAELKPWYEPMYLGGVFQLEKGDLL
SAEVNLPKYLDITESGQVYFGVIAL

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000001110
UniGene Rn.2275
PDB
RefSeq NP_036807.1
Pfam PF00229