thioredoxin reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term thioredoxin reductase
UniProt ID PRDX5_MOUSE
Name Peroxiredoxin V
PLP
Thioredoxin reductase
Peroxiredoxin-5, mitochondrial
Liver tissue 2D-page spot 2D-0014IV
Peroxisomal antioxidant enzyme
AOEB166
Thioredoxin peroxidase PMP20
Prx-V
Antioxidant enzyme B166
Gene Names Prdx5
Synonyms:Prdx6
Taxonomy Mus musculus

General annotation

Function Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.
Subcellular location Mitochondrion. Cytoplasm. Peroxisome.

Gene Ontology

GO:0051920 peroxiredoxin activity MF
GO:0004601 peroxidase activity MF
GO:0005739 mitochondrion CC
GO:0005777 peroxisome CC

Sequence

>gi|6755114|ref|NP_036151.1| peroxiredoxin-5, mitochondrial precursor [Mus musculus]
MLQLGLRVLGCKASSVLRASTCLAGRAGRKEAGWECGGARSFSSSAVTMAPIKVGDAIPSVEVFEGEPGK
KVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAGALKAKGAQVVACLSVNDVFVIEEWGRAHQAE
GKVRLLADPTGAFGKATDLLLDDSLVSLFGNRRLKRFSMVIDNGIVKALNVEPDGTGLTCSLAPNILSQL

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Database Cross Reference

Ensembl Gene ENSMUST00000025904
UniGene Mm.279782
PDB
RefSeq NP_036151.1
Pfam PF08534