thioredoxin reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term thioredoxin reductase
UniProt ID PRDX5_RAT
Name AOEB166
PLP
Thioredoxin peroxidase PMP20
Peroxisomal antioxidant enzyme
Peroxiredoxin-5, mitochondrial
Thioredoxin reductase
Prx-V
Peroxiredoxin V
Antioxidant enzyme B166
Gene Names Prdx5
Taxonomy Rattus norvegicus

General annotation

Function Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling (By similarity).
Subcellular location Mitochondrion (By similarity). Cytoplasm (By similarity). Peroxisome (By similarity).

Gene Ontology

GO:0005777 peroxisome CC
GO:0004601 peroxidase activity MF
GO:0005739 mitochondrion CC
GO:0051920 peroxiredoxin activity MF

Sequence

>gi|16758404|ref|NP_446062.1| peroxiredoxin-5, mitochondrial precursor [Rattus norvegicus]
MVQLRFCVLGSIAGSVLRASATWTCVAGRAGRKGAGWECGGARSFSSAAVTMAPIKVGDTIPSVEVFEGE
PGKKVNLAELFKDKKGVLFGVPGAFTPGCSKTHLPGFVEQAGALKAKGAQVVACLSVNDAFVTAEWGRAH
QAEGKVQLLADPTGAFGKETDLLLDDSLVSLFGNRRLKRFSMVIDKGVVKALNVEPDGTGLTCSLAPNIL
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Database Cross Reference

Ensembl Gene ENSRNOT00000028687
UniGene Rn.2944
PDB
RefSeq NP_446062.1
Pfam PF08534