apical sodium dependent bile acid transporter

General Information (Source: NCBI Gene,UniProt)

Text mining Term apical sodium dependent bile acid transporter
UniProt ID NTCP2_MOUSE
Name ISBT
ASBT
Ileal Na(+)/bile acid cotransporter
Sodium/taurocholate cotransporting polypeptide, ileal
Solute carrier family 10 member 2
Ileal sodium-dependent bile acid transporter
Apical sodium-dependent bile acid transporter
IBAT
Na(+)-dependent ileal bile acid transporter
Ileal sodium/bile acid cotransporter
Gene Names Slc10a2
Synonyms:Ntcp2
Taxonomy Mus musculus

General annotation

Function Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity).
Subcellular location Membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0015711 organic anion transport BP
GO:0016021 integral to membrane CC

Sequence

>gi|6755530|ref|NP_035518.1| ileal sodium/bile acid cotransporter [Mus musculus]
MDNSSVCPPNATVCEGDSCVVPESNFNAILNTVMSTVLTILLAMVMFSMGCNVEVHKFLGHIKRPWGIFV
GFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGM
MPLCLFVYTKMWVDSGTIVIPYDSIGISLVALVIPVSFGMFVNHKWPQKAKIILKIGSITGVILIVLIAV
IGGILYQSAWIIEPKLWIIGTIFPIAGYSLGFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSP
EDLNLVFTFPLIYTVFQLVFAAVILGIYVTYRKCYGKNDAEFLEKTDNEMDSRPSFDETNKGFQPDEK

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Database Cross Reference

Ensembl Gene ENSMUST00000023835
UniGene Mm.3500
PDB
RefSeq NP_035518.1
Pfam PF01758