PGDH

General Information (Source: NCBI Gene,UniProt)

Text mining Term PGDH
UniProt ID PGDH_RAT
Name Prostaglandin dehydrogenase 1
15-hydroxyprostaglandin dehydrogenase [NAD+]
15-PGDH
Gene Names Hpgd
Synonyms:Pgdh1
Taxonomy Rattus norvegicus

General annotation

Function Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).
Subcellular location Cytoplasm (By similarity).

Gene Ontology

GO:0007179 transforming growth factor beta receptor signaling pathway BP
GO:0007565 female pregnancy BP
GO:0030728 ovulation BP
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity MF
GO:0070493 thrombin receptor signaling pathway BP
GO:0007567 parturition BP
GO:0097070 ductus arteriosus closure BP
GO:0045786 negative regulation of cell cycle BP
GO:0006693 prostaglandin metabolic process BP
GO:0004957 prostaglandin E receptor activity MF
GO:0070403 NAD+ binding MF
GO:0005737 cytoplasm CC

Sequence

>gi|40538858|ref|NP_077366.2| 15-hydroxyprostaglandin dehydrogenase [NAD+] [Rattus norvegicus]
MHVNGKVALVTGAAQGIGKAFTEALLLHGAKVALVDWNLETGVKCKAALDEQFEPQKTLFIQCDVADQKQ
LRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINISSIA
GLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVKTPILESIEKEENMGQYIEYTDQI
KAMMKFYGILDPSAIANGLINLIEDDALNGAIMKITASKGIHFQDYDLFPSFSKAP

Options for BLAST

Database:

Set subsequence:(optional):
From: To:

Optional parameters:
Expect:
Descriptions:

Database Cross Reference

Ensembl Gene ENSRNOT00000014229
UniGene Rn.6386
PDB
RefSeq NP_077366.2
Pfam PF00106